ReviewJournal of diabetes and metabolic disorders2020
Type 2 diabetes mellitus: pathogenesis and genetic diagnosis.
Review in Journal of diabetes and metabolic disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 74 citations in OpenAlex.
- Therapeutic Effects of ProbioticFood science & nutrition · 2026Article
- Diabetes: A comprehensive review of the Indian landscape in contrast with global trends.World journal of diabetes · 2026Review
- Mechanism and application ofFrontiers in cellular and infection microbiology · 2026Review
- Serum uric acid to HDL-Chol ratio (UHR) is associated with insulin resistance/sensitivity in individuals without diabetes.Acta diabetologica · 2026Article
- Investigation of the association between MSR1 serum levels and type 2 diabetes: a preliminary study.Irish journal of medical science · 2025Article
- GLP-1 and Its Role in Glycogen Production: A Narrative Review.Biomedicines · 2025Review
- Genetics of diabetes and its complications: a comprehensive review.Diabetology & metabolic syndrome · 2025Review
- The role of avocado plant and its derivatives in the management of diabetes mellitus: a natural approach to glycemic control.Journal of diabetes and metabolic disorders · 2025Review
- Development and validation of a prognostic model for critically ill type 2 diabetes patients in ICU based on composite inflammatory indicators.Scientific reports · 2025Article
- Article
- Interplay of fatty acids, insulin and exercise in vascular health.Lipids in health and disease · 2025Review
- A Scoping Review of Glucose Spikes in People Without Diabetes: Comparing Insights from Grey Literature and Medical Research.Clinical medicine insights. Endocrinology and diabetes · 2025Article
- Exploring the therapeutic potential ofIn silico pharmacology · 2025Article
- Palmitic acid and eicosapentaenoic acid supplementation in 3T3 adipocytes: impact on lipid storage and oxidative stress.Redox report : communications in free radical research · 2024Article
- Article
- Association of meleanocortin 4 receptor gene polymorphism (MC4R:C.92C>T) with feline diabetes.Journal of advanced veterinary and animal research · 2024Article
- Autoantibodies against beta cells to predict early insulin requirements in pediatric patients with clinically diagnosed type 2 diabetes.World journal of diabetes · 2024Article
- Nutritional load in post-prandial oxidative stress and the pathogeneses of diabetes mellitus.NPJ science of food · 2024Article
- Network Pharmacology Analysis, Molecular Docking Integrated Experimental Verification Reveal the Mechanism ofCurrent issues in molecular biology · 2024Article
- Relationship between Polyunsaturated Fatty Acid Metabolism and Atherosclerosis.Reviews in cardiovascular medicine · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Type 2 diabetes mellitus (T2DM) is a heterogeneous condition that is related to both defective insulin secretion and peripheral insulin resistance. Beta cells are the major organ for secreting insulin hence, it is important to maintain an adequate beta-cell mass in response to various changes. Insulin resistance is a major cause of T2DM leads to elevated free fatty acid (FFA) levels which increases beta-cell mass and insulin secretion to compensate for insulin insensitivity. Chronic increase of plasma FFA levels results in disturbances in lipid metabolism, which contributes to decreased beta-cell function and lipotoxicity thus promoting T2DM. In the present review, we have discussed the process of beta-cell destruction, the role of genes in contributing to the fast increase in the progression of T2DM in detail. More than 130 variants in various T2DM susceptibility and candidate genes have been discovered to be associated with T2DM. Still, these variants elucidate only a small amount of total heritability of T2DM. Further, there is also an inventory of presently used therapeutic tools and a review of novel therapeutic approaches like incretin-based therapies or sodium-glucose transporter-2 inhibitors. Additionally, providing a concise but comprehensive update, this review will be essential to every clinician involved in the treatment of diabetes mellitus.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.