Trial reportPain reports
Essential statistical principles of clinical trials of pain treatments.
Trial report in Pain reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- Primary 3-Month Outcomes of a Double-Blind Randomized Prospective Study (The QUEST Study) Assessing Effectiveness and Safety of Novel High-Frequency Electric Nerve Block System for Treatment of Post-Amputation Pain.Journal of pain research · 2024Trial
- A randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of a bupivacaine hydrochloride implant in patients undergoing abdominoplasty.Regional anesthesia and pain medicine · 2023Trial
- The ACTTION Guide to Clinical Trials of Pain Treatments, part II: mitigating bias, maximizing value.Pain reportsTrial
- Initial efforts of translational development of AAV-encoded NaMolecular therapy. Advances · 2026Article
- Article
- Sensory and cortical biomarkers unveil pain modulation mechanisms induced by targeted multisensory neurostimulation.Journal of neuroengineering and rehabilitation · 2026Article
- Article
- Tecovirimat for the Treatment of Mpox.The New England journal of medicine · 2026Article
- Pharmacogenetic-Guided Antidepressant Prescribing in Adolescents (PGx-GAP): Study Protocol for a Randomized Controlled Trial.Journal of personalized medicine · 2026Article
- Designing a Digital Twin for the Management of Noncommunicable Diseases: Protocol for a Pilot Study and Methodology Validation.JMIR research protocols · 2026Article
- Adverse effects and perceived benefits of medications in children with chronic noncancer pain.Frontiers in pain research (Lausanne, Switzerland) · 2026Article
- FDA-Regulated Clinical Trials vs. Real-World Data: How to Bridge the Gap in Pain Research.Brain sciences · 2025Review
- Risks and Benefits of Pharmacological Treatment for Pediatric Chronic Non-cancer Pain: When Safety Evidence Lags Behind Prescription Pads.Paediatric drugs · 2025Review
- Protocol Development for Investigator-Sponsored Clinical Studies.Clinical and translational science · 2025Article
- Justice for Placebo: Placebo Effect in Clinical Trials and Everyday Practice.Medicines (Basel, Switzerland) · 2025Review
- Ethical and academic dilemmas in authorship of clinical research publications: a medical oncologist's perspective.Medical oncology (Northwood, London, England) · 2025Review
- Wearable non-invasive neuroprosthesis for targeted sensory restoration in neuropathy.Nature communications · 2024Article
- Advancing Pain Understanding and Drug Discovery: Insights from Preclinical Models and Recent Research Findings.Pharmaceuticals (Basel, Switzerland) · 2024Review
- A Spicy New Treatment for Postoperative Pain.Anesthesiology · 2024Article
- Commentary on 2022 guidelines on clinical trial design in cluster headache and further suggestions.The journal of headache and pain · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This article presents an overview of fundamental statistical principles of clinical trials of pain treatments. Statistical considerations relevant to phase 2 proof of concept and phase 3 confirmatory randomized trials investigating efficacy and safety are discussed, including (1) research design; (2) endpoints and analyses; (3) sample size determination and statistical power; (4) missing data and trial estimands; (5) data monitoring and interim analyses; and (6) interpretation of results. Although clinical trials of pharmacologic treatments are emphasized, the key issues raised by these trials are also directly applicable to clinical trials of other types of treatments, including biologics, devices, nonpharmacologic therapies (eg, physical therapy and cognitive-behavior therapy), and complementary and integrative health interventions.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.