Evidence map›Paper›PMID 33524161›Full record

ArticleImmunology2021

Human CD36

Jessica G Lee, Kathleen E Jaeger, Yoichi Seki, Yi Wei Lim, Christina Cunha, Aleksandra Vuchkovska, Alexander J Nelson, Anya Nikolai, Dan Kim, Michael Nishimura and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in Immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. CD36 and Its Role in Regulating the Tumor Microenvironment.Current oncology (Toronto, Ont.) · 2022
    Review
  6. Review
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Jessica G LeeDepartment of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL, USA.
Kathleen E JaegerDepartment of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL, USA.
Yoichi SekiDepartment of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL, USA.
Yi Wei LimDepartment of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL, USA.
Christina CunhaDepartment of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL, USA.
Aleksandra VuchkovskaDepartment of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL, USA.
Alexander J NelsonDepartment of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL, USA.
Anya NikolaiDepartment of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL, USA.
Dan KimDepartment of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL, USA.
Michael NishimuraDepartment of Surgery, Stritch School of Medicine, Loyola University Chicago, Maywood, IL, USA.
Katherine L KnightDepartment of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL, USA.
Paula WhiteDepartment of Obstetrics and Gynecology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL, USA.
Makio IwashimaDepartment of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL, USA.ORCID 0000-0003-3849-0212
Loyola University Chicago · US

Funding

Spatial control of Ca2+ signals in lymphocytesR01AI055022 · NIAID · MEDICAL COLLEGE OF GEORGIA (MCG) · PI IWASHIMA, MAKIO · 2003 to 2007
$1.4M
Determining intracellular signaling events that control CAR T cell death in vivo.F31CA243228 · NCI · LOYOLA UNIVERSITY CHICAGO · PI CUNHA, CHRISTINA ROSE · 2019 to 2020
$64k
NCI NIH HHS F31 CA243228NIAID NIH HHS R01 AI055022
6 · The paper itself

Abstract

The fetal and neonatal immune systems are uniquely poised to generate tolerance to self, maternal and environmental antigens encountered in the womb and shortly after birth. However, the tolerogenic nature of fetal and neonatal immunity can be detrimental in the context of pathogens, leading to overwhelming bacterial infections or chronic viral infections. A variety of mechanisms contribute to fetal and neonatal tolerance, including a propensity to generate Foxp3

Indexed as

AdultCD36 AntigensCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell DifferentiationCells, CulturedFetal BloodFetusForkhead Transcription FactorsGraft vs Host DiseaseHumansImmune ToleranceImmunosuppression TherapyLymphocyte ActivationMonocytesT-bet Transcription FactorCD36 AntigensForkhead Transcription FactorsFOXP3 protein, humanT-bet Transcription FactorT-Box Domain ProteinsCD36fetal toleranceFoxp3monocytesT-betTreg

Identifiers

PMID33524161
PMCPMC8207412
OpenAlexW3128450451

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.