ArticleCommunications biology2021
Molecular characterization of a marine turtle tumor epizootic, profiling external, internal and postsurgical regrowth tumors.
Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
- Fibropapillomatosis Dynamics, Severity and Demographic Effect in Caribbean Green Turtles.EcoHealth · 2025Article
- Epidemiology of marine turtle fibropapillomatosis and tumour-associated chelonid alphaherpesvirus 5 (ChHV5; Scutavirus chelonidalpha5) in North-Western Mexico: a scoping review implementing the one health approach.Veterinary research communications · 2024Article
- International overview of sea turtle fibropapillomatosis: a survey of expert opinions and trends.Frontiers in cell and developmental biology · 2024Article
- Case report: Diagnosis and autogenous vaccine treatment of herpesvirus in a green turtle (Frontiers in veterinary science · 2024Article
- Green Turtle Fibropapillomatosis: Tumor Morphology and Growth Rate in a Rehabilitation Setting.Veterinary sciences · 2023Article
- Preparation of recombinant glycoprotein B (gB) of Chelonid herpesvirus 5 (ChHV5) for antibody production and its application for infection detection in sea turtles.Scientific reports · 2022Article
- Adaptive evolution of major histocompatibility complex class I immune genes and disease associations in coastal juvenile sea turtles.Royal Society open science · 2022Article
- Sea Turtles in the Cancer Risk Landscape: A Global Meta-Analysis of Fibropapillomatosis Prevalence and Associated Risk Factors.Pathogens (Basel, Switzerland) · 2021Article
- Evolutionary Comparisons of Chelonid Alphaherpesvirus 5 (ChHV5) Genomes from Fibropapillomatosis-Afflicted Green (Animals : an open access journal from MDPI · 2021Article
- Environmental DNA monitoring of oncogenic viral shedding and genomic profiling of sea turtle fibropapillomatosis reveals unusual viral dynamics.Communications biology · 2021Article
- Insights on Immune Function in Free-Ranging Green Sea Turtles (Animals : an open access journal from MDPI · 2021Article
- The Concurrent Detection of Chelonid Alphaherpesvirus 5 andAnimals : an open access journal from MDPI · 2021Article
- Article
- Genotype data not consistent with clonal transmission of sea turtle fibropapillomatosis or goldfish schwannoma.Wellcome open research · 2021Article
- Transcriptomic Profiling of Fibropapillomatosis in Green Sea Turtles (Frontiers in immunology · 2021Article
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Authors and funding
21 authors at 7 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sea turtle populations are under threat from an epizootic tumor disease (animal epidemic) known as fibropapillomatosis. Fibropapillomatosis continues to spread geographically, with prevalence of the disease also growing at many longer-affected sites globally. However, we do not yet understand the precise environmental, mutational and viral events driving fibropapillomatosis tumor formation and progression.Here we perform transcriptomic and immunohistochemical profiling of five fibropapillomatosis tumor types: external new, established and postsurgical regrowth tumors, and internal lung and kidney tumors. We reveal that internal tumors are molecularly distinct from the more common external tumors. However, they have a small number of conserved potentially therapeutically targetable molecular vulnerabilities in common, such as the MAPK, Wnt, TGFβ and TNF oncogenic signaling pathways. These conserved oncogenic drivers recapitulate remarkably well the core pan-cancer drivers responsible for human cancers. Fibropapillomatosis has been considered benign, but metastatic-related transcriptional signatures are strongly activated in kidney and established external tumors. Tumors in turtles with poor outcomes (died/euthanized) have genes associated with apoptosis and immune function suppressed, with these genes providing putative predictive biomarkers.Together, these results offer an improved understanding of fibropapillomatosis tumorigenesis and provide insights into the origins, inter-tumor relationships, and therapeutic treatment for this wildlife epizootic.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.