ArticleNeurobiology of stress2021
To stress or not to stress: Brain-behavior-immune interaction may weaken or promote the immune response to SARS-CoV-2.
Article in Neurobiology of stress, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Association of open-plan offices and sick leave-a systematic review and meta-analysis.Industrial health · 2023Pooled it
- The relationship between psychological stress and SARS-CoV-2 nucleocapsid-antibody response following natural infection: longitudinal findings from the Aegis study.American journal of epidemiology · 2026Article
- Long COVID and Its Impact on Daily Functioning: Findings from the Si-Panda Behavioural Insights Survey in Slovenia.Zdravstveno varstvo · 2026Article
- No Genetic Causal Relationship between COVID-19 and Herpes Zoster: A Bidirectional Mendelian Randomization Analysis.Journal of multidisciplinary healthcare · 2025Article
- Exploring the complex mechanisms of post-intracerebral hemorrhage depression: towards personalized treatment approaches.Frontiers in psychiatry · 2025Review
- What Lessons can Be Learned From the Management of the COVID-19 Pandemic?International journal of public health · 2025Review
- (Fear of) SARS-CoV-2 infection and psychological distress: a population-based cohort study in southern Switzerland.Epidemiology and psychiatric sciences · 2024Article
- [S1 guideline long/post-COVID syndrome].Urologie (Heidelberg, Germany) · 2024Article
- Age and Hair Cortisol Levels as Predictors of SARS-CoV-2 Infection.International journal of environmental research and public health · 2024Article
- The interplay between previous infection and mental health condition on antibody response to COVID-19 mRNA vaccination.Brain, behavior, & immunity - health · 2023Article
- Perspectives of (/memorandum for) systems thinking on COVID-19 pandemic and pathology.Journal of evaluation in clinical practice · 2023Article
- Unintended Consequences of COVID-19 Non-Pharmaceutical Interventions (NPIs) for Population Health and Health Inequalities.International journal of environmental research and public health · 2023Review
- Increases in stress hormone levels in a UK population during the COVID-19 pandemic: A prospective cohort study.Psychoneuroendocrinology · 2023Article
- Bidirectional crosstalk between the peripheral nervous system and lymphoid tissues/organs.Frontiers in immunology · 2023Review
- Observational
- Potential of macronutrients and probiotics to boost immunity in patients with SARS-COV-2: a narrative review.Frontiers in nutrition · 2023Review
- 2nd European Psychoneuroimmunology Network Autumn School: The Skin-Brain Axis and the Breaking of Barriers.Neuroimmunomodulation · 2023Article
- Religious coping and young adult's mental well-being during Covid-19: Testing a double moderated mediation model.Archive for the psychology of religion = Archiv fur Religionspsychologie · 2022Article
- Allostatic load in the context of disasters.Psychoneuroendocrinology · 2022Review
- The impact of short-term confinement on human innate immunity.Scientific reports · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The COVID-19 pandemic continues to strongly affect people with health disadvantages, creating a heavy burden on medical systems and societies worldwide. Research is growing rapidly and recently revealed that stress-related factors such as socio-economic status, may also play a pivotal role. However, stress research investigating the underlying psychoneuroimmune interactions is missing. Here we address the question whether stress-associated neuroendocrine-immune mechanisms can possibly contribute to an increase in SARS-CoV-2 infections and influence the course of COVID-19 disease. Additionally, we discuss that not all forms of stress (e.g. acute versus chronic) are detrimental and that some types of stress could attenuate infection-risk and -progression. The overall aim of this review is to motivate future research efforts to clarify whether psychosocial interventions have the potential to optimize neuroendocrine-immune responses against respiratory viral infections during and beyond the COVID-19 pandemic. The current state of research on different types of stress is summarized in a comprehensive narrative review to promote a psychoneuroimmune understanding of how stress and its mediators cortisol, (nor)adrenaline, neuropeptides and neurotrophins can shape the immune defense against viral diseases. Based on this understanding, we describe how people with high psychosocial stress can be identified, which behaviors and psychosocial interventions may contribute to optimal stress management, and how psychoneuroimmune knowledge can be used to improve adequate care for COVID-19 and other patients with viral infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.