Evidence map›Paper›PMID 33527749›Full record

ArticlePhysiological reports2021

The association between lactate and muscle aerobic substrate oxidation: Is lactate an early marker for metabolic disease in healthy subjects?

Nicholas T Broskey, Walter J Pories, Terry E Jones, Charles J Tanner, Donghai Zheng, Ronald N Cortright, Zhen W Yang, Nkaujyi Khang, Josh Yang, Joseph A Houmard and 1 more

Open access · goldAbstract read
In one paragraph

Article in Physiological reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Lactate Metabolism in Health and Disease.Advances in experimental medicine and biology · 2025
    Review
  4. Article
  5. Delayed and diminished postprandial lactate shuttling in healthy older men and women.American journal of physiology. Endocrinology and metabolism · 2024
    Article
  6. Observational
  7. Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Nicholas T BroskeyDepartment of Kinesiology, East Carolina University, Greenville, North Carolina, USA.ORCID 0000-0002-1197-5116
Walter J PoriesDepartment of Diabetes, Obesity Institute, East Carolina University, Greenville, North Carolina, USA.
Terry E JonesDepartment of Diabetes, Obesity Institute, East Carolina University, Greenville, North Carolina, USA.
Charles J TannerDepartment of Kinesiology, East Carolina University, Greenville, North Carolina, USA.
Donghai ZhengDepartment of Kinesiology, East Carolina University, Greenville, North Carolina, USA.
Ronald N CortrightDepartment of Kinesiology, East Carolina University, Greenville, North Carolina, USA.
Zhen W YangDepartment of Kinesiology, East Carolina University, Greenville, North Carolina, USA.
Nkaujyi KhangDepartment of Kinesiology, East Carolina University, Greenville, North Carolina, USA.
Josh YangDepartment of Physiology, East Carolina University, Greenville, North Carolina, USA.
Joseph A HoumardDepartment of Kinesiology, East Carolina University, Greenville, North Carolina, USA.
G Lynis DohmDepartment of Diabetes, Obesity Institute, East Carolina University, Greenville, North Carolina, USA.
East Carolina University · US

Funding

LIPID METABOLISM IN OBESITY, WEIGHT LOSS AND EXERCISER01DK056112 · NIDDK · EAST CAROLINA UNIVERSITY · PI HOUMARD, JOSEPH A · 2000 to 2016
$4.5M
Metabolic inflexibility is related to elevated muscle anaerobic glycolysisR01DK120296 · NIDDK · EAST CAROLINA UNIVERSITY · PI BROSKEY, NICHOLAS, HOUMARD, JOSEPH A · 2019 to 2023
$2.6M
NIDDK NIH HHS 120296NIDDK NIH HHS 56112NIDDK NIH HHS R01 DK120296
6 · The paper itself

Abstract

Fasting plasma lactate concentrations are elevated in individuals with metabolic disease. The aim of this study was to determine if the variance in fasting lactate concentrations were associated with factors linked with cardiometabolic health even in a young, lean cohort. Young (age 22 ± 0.5; N = 30) lean (BMI (22.4 ± 0.4 kg/m

Indexed as

Cardiorespiratory FitnessEnergy MetabolismMuscle ContractionBiomarkersCardiometabolic Risk FactorsFemaleHealth StatusHealthy VolunteersHumansLactic AcidMetabolic DiseasesMitochondria, MusclePredictive Value of TestsQuadriceps MuscleRisk AssessmentYoung AdultBiomarkersLactic Acidaerobic fitnesslactatemetabolismmitochondriaskeletal muscle

Identifiers

PMID33527749
PMCPMC7851428
OpenAlexW3127089350

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.