ArticleJournal of sport and health science2023
Chronotropic incompetence is more frequent in obese adolescents and relates to systemic inflammation and exercise intolerance.
Article in Journal of sport and health science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Chronotropic Incompetence Among People With HIV Improves With Exercise Training in the Exercise for Healthy Aging Study.The Journal of infectious diseases · 2024Trial
- Impact of a multidisciplinary intervention on resting and exercise respiratory functions in adolescents with obesity.Pediatric research · 2026Article
- The Role of Exercise in Fat Oxidation and Its Impact on Adolescent Metabolism.Advances in experimental medicine and biology · 2026Review
- Impaired oxygen consumption kinetics and autonomic dysfunction contribute to increased fatigue in obese young males during sustained exercise.Journal of exercise rehabilitation · 2025Article
- Chronotropic Response and Risk Factors for Cardiovascular Disease in Patients with Rheumatoid Arthritis: A Cross-Sectional Study.Journal of clinical medicine · 2023Article
- Chronotropic Incompetence among People with HIV Improves with Exercise Training in the Exercise for Healthy Aging Study.medRxiv : the preprint server for health sciences · 2023Article
- Rate-Responsive Cardiac Pacing: Technological Solutions and Their Applications.Sensors (Basel, Switzerland) · 2023Review
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdults with obesity may display disturbed cardiac chronotropic responses during cardiopulmonary exercise testing, which relates to poor cardiometabolic health and an increased risk for adverse cardiovascular events. It is unknown whether cardiac chronotropic incompetence (CI) during maximal exercise is already present in obese adolescents and, if so, how that relates to cardiometabolic health.
methodsSixty-nine obese adolescents (body mass index standard deviation score = 2.23 ± 0.32, age = 14.1 ± 1.2 years; mean ± SD) and 29 lean adolescents (body mass index standard deviation score = -0.16 ± 0.84, age = 14.0 ± 1.5 years) performed a maximal cardiopulmonary exercise testing from which indicators for peak performance were determined. The resting heart rate and peak heart rate were used to calculate the maximal chronotropic response index. Biochemistry (lipid profile, glycemic control, inflammation, and leptin) was studied in fasted blood samples and during an oral glucose tolerance test within obese adolescents. Regression analyses were applied to examine associations between the presence of CI and blood or exercise capacity parameters, respectively, within obese adolescents.
resultsCI was prevalent in 32 out of 69 obese adolescents (46%) and 3 out of 29 lean adolescents (10%). C-reactive protein was significantly higher in obese adolescents with CI compared to obese adolescents without CI (p = 0.012). Furthermore, peak oxygen uptake and peak cycling power output were significantly reduced (p < 0.05) in obese adolescents with CI vs. obese adolescents without CI. The chronotropic index was independently related to blood total cholesterol (standardized coefficient β = -0.332; p = 0.012) and C-reactive protein concentration (standardized coefficient β = -0.269; p = 0.039).
conclusionCI is more common in the current cohort of obese adolescents, and is related to systemic inflammation and exercise intolerance.
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