Evidence map›Paper›PMID 33531372›Full record

ArticleCancer research2021

Premalignant Oligodendrocyte Precursor Cells Stall in a Heterogeneous State of Replication Stress Prior to Gliomagenesis.

Matthew D Sutcliffe, Rui P Galvao, Lixin Wang, Jungeun Kim, Lauren K Rosenfeld, Shambhavi Singh, Hui Zong, Kevin A Janes

Open access · bronzeAbstract readComment
In one paragraph

Article in Cancer research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Matthew D SutcliffeDepartment of Biomedical Engineering, University of Virginia, Charlottesville, Virginia.ORCID 0000-0002-2139-6732
Rui P GalvaoDepartment of Microbiology, Immunology & Cancer Biology, University of Virginia, Charlottesville, Virginia.
Lixin WangDepartment of Biomedical Engineering, University of Virginia, Charlottesville, Virginia.
Jungeun KimDepartment of Microbiology, Immunology & Cancer Biology, University of Virginia, Charlottesville, Virginia.
Lauren K RosenfeldDepartment of Microbiology, Immunology & Cancer Biology, University of Virginia, Charlottesville, Virginia.
Shambhavi SinghDepartment of Biomedical Engineering, University of Virginia, Charlottesville, Virginia.ORCID 0000-0002-6961-2289
Hui ZongDepartment of Microbiology, Immunology & Cancer Biology, University of Virginia, Charlottesville, Virginia. kjanes@virginia.edu hz9s@virginia.edu.ORCID 0000-0002-4263-9633
Kevin A JanesDepartment of Biomedical Engineering, University of Virginia, Charlottesville, Virginia. kjanes@virginia.edu hz9s@virginia.edu.
University of Virginia · US

Funding

Women's Oncology Program - WONP30CA044579 · NCI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Jay William FOX · 1987 to 2026
$72.1M
An Integrated Systems Approach for Incompletely Penetrant Onco-phenotypes.U01CA215794 · NCI · UNIVERSITY OF VIRGINIA · PI JANES, KEVIN A · 2017 to 2021
$2.4M
(PQB4) Stochastic Profiling of Functional Single-Cell States Within Solid TumorsR01CA194470 · NCI · UNIVERSITY OF VIRGINIA · PI JANES, KEVIN A · 2015 to 2018
$1.8M
Characterizing the glioma cell of origin in vivo using MADM, a mouse genetic mosaR01CA136495 · NCI · UNIVERSITY OF VIRGINIA · PI ZONG, HUI · 2010 to 2015
$1.7M
Interdisciplinary Training in Systems & Biomolecular Data ScienceT32GM145443 · NIGMS · UNIVERSITY OF VIRGINIA · PI Kevin A Janes, Jason Papin · 2022 to 2026
$1.5M
NCI NIH HHS P30 CA044579NCI NIH HHS R01 CA136495NCI NIH HHS R01 CA194470NCI NIH HHS U01 CA215794NIGMS NIH HHS T32 GM145443
6 · The paper itself

Abstract

Cancer evolves from premalignant clones that adopt unusual cell states to achieve transformation. We previously pinpointed the oligodendrocyte precursor cell (OPC) as a cell of origin for glioma, but the early changes of mutant OPCs during premalignancy remained unknown. Using mice engineered for inducible

Indexed as

GliomaOligodendrocyte Precursor CellsAnimalsCell Transformation, NeoplasticDNA-Binding ProteinsEndonucleasesFemaleHumansMiceOligodendrogliaRNA-Binding ProteinsDNA-Binding ProteinsEndonucleasesMUS81 protein, humanRAD51C protein, mouseRNA-Binding ProteinsUPF3B protein, mouse

Identifiers

PMID33531372
PMCPMC8137536
OpenAlexW3126653056

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.