Evidence map›Paper›PMID 33534728›Full record

SynthesisDiabetes care2020

Efficacy of Modern Diabetes Treatments DPP-4i, SGLT-2i, and GLP-1RA in White and Asian Patients With Diabetes: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Sushrima Gan, Adem Y Dawed, Louise A Donnelly, Anand T N Nair, Colin N A Palmer, Viswanathan Mohan, Ewan R Pearson

Open access · greenAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Diabetes care, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 5 pooled it
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 5 syntheses or guidelines pooled it, 78 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Sushrima GanUniversity of Dundee, Dundee, U.K.
Adem Y DawedUniversity of Dundee, Dundee, U.K.ORCID 0000-0003-0224-2428
Louise A DonnellyUniversity of Dundee, Dundee, U.K.
Anand T N NairUniversity of Dundee, Dundee, U.K.
Colin N A PalmerUniversity of Dundee, Dundee, U.K.
Viswanathan MohanMadras Diabetes Research Foundation & Dr. Mohan's Diabetes Specialities Centre, Chennai, India.ORCID 0000-0001-5038-6210
Ewan R PearsonUniversity of Dundee, Dundee, U.K. e.z.pearson@dundee.ac.uk.ORCID 0000-0001-9237-8585
University of Dundee · GBMadras Diabetes Research Foundation · IN

Funding

Wellcome TrustWellcome Trust 102820/Z/13/Z
6 · The paper itself

Abstract

backgroundThe pathophysiology of type 2 diabetes differs markedly by ethnicity. PURPOSE: A systematic review and meta-analysis was conducted to assess the impact of ethnicity on the glucose-lowering efficacy of the newer oral agents, sodium-glucose cotransporter 2 inhibitors (SGLT-2i), glucagon-like peptide 1 receptor agonists (GLP-1RA), and dipeptidyl peptidase 4 inhibitors (DPP-4i), using evidence from randomized clinical trials (RCTs). DATA SOURCES: A literature search was conducted in PubMed of all randomized, placebo-controlled trials of DPP-4i, SGLT-2i, and GLP-1RA. The search strategy was developed based on Medical Subject Headings (MeSH) terms and keywords. STUDY SELECTION: A total of 64 studies that qualified for meta-analysis after full-text review based on predefined inclusion and exclusion criteria-RCTs with at least 50 patients in each arm, >70% of population from Asian or white group, duration ≥24 weeks, and publication up to March 2019-were selected for systematic review and meta-analysis. DATA EXTRACTION: Data extraction was done for aggregated study-level data by two independent researchers. Absolute changes in HbA DATA SYNTHESIS: Change in HbA LIMITATIONS: The study is based on summarized data and could not be separated based on East Asians and South Asians.

conclusionsThe glucose-lowering efficacy of SGLT-2i, and to a lesser extent DPP-4i, was greater in studies of predominantly Asian ethnicity compared with studies of predominantly white ethnicity. There was no difference seen by ethnicity for GLP-1RA.

Indexed as

Asian PeopleDiabetes MellitusDipeptidyl-Peptidase IV InhibitorsGlucagon-Like Peptide ReceptorsHumansRandomized Controlled Trials as TopicSodium-Glucose Transporter 2 InhibitorsWhite PeopleDipeptidyl-Peptidase IV InhibitorsGlucagon-Like Peptide ReceptorsSodium-Glucose Transporter 2 Inhibitors

Identifiers

PMID33534728
PMCPMC7372059
OpenAlexW3042485772

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.