Specific protein kinase C isoform exerts chronic inhibition on the slowly activating delayed-rectifier potassium current by affecting channel trafficking.

Xiangbo Gou, Tingting Hu, Yu Gou, Chaoqi Li, Ming Yi, Mengran Jia

Abstract read

In one paragraph

Article in Channels (Austin, Tex.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it

0cells of the map it votes in

3citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

Angiotensin receptors and αPflugers Archiv : European journal of physiology · 2024
Article
Divergent regulation of KCNQ1/E1 by targeted recruitment of protein kinase A to distinct sites on the channel complex.eLife · 2023
Article
Long-QT mutations in KCNE1 modulate the 17β-estradiol response of Kv7.1/KCNE1.Science advances · 2023
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiangbo GouTianjin Key Labortory of Drug Targeting and Bioimaging, Tianjin University of Technology , Tianjin, China.ORCID 0000-0003-1616-6729

Tingting HuDepartment of Orthopaedic Surgery, Tianjin Hospital, Tianjin University , Tianjin, China.

Yu GouDepartment of Orthopaedic Surgery, Tianjin Hospital, Tianjin University , Tianjin, China.

Chaoqi LiSchool of Chemistry and Chemical Engineering, Tianjin University of Technology , Tianjin, China.

Ming YiSchool of Chemistry and Chemical Engineering, Tianjin University of Technology , Tianjin, China.

Mengran JiaSchool of Chemistry and Chemical Engineering, Tianjin University of Technology , Tianjin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The slowly activating delayed rectifier K

Indexed as

Protein TransportAngiotensin IIHEK293 CellsHumansIsoenzymesKCNQ1 Potassium ChannelPotassium Channels, Voltage-GatedProtein Kinase CProtein Kinase C-epsilonTetradecanoylphorbol AcetateAngiotensin IIIsoenzymesKCNE1 protein, humanKCNQ1 Potassium ChannelKCNQ1 protein, humanPotassium Channels, Voltage-GatedProtein Kinase CProtein Kinase C-epsilonTetradecanoylphorbol AcetateI ksintracellular traffickingion channelKCNQ1Protein kinase C

Identifiers

PMID33535882

DOI10.1080/19336950.2021.1882112

PMCPMC7872027

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.