Evidence map›Paper›PMID 33536010›Full record

Trial reportBMC musculoskeletal disorders2021

The comparison effects of intra-articular injection of Platelet Rich Plasma (PRP), Plasma Rich in Growth Factor (PRGF), Hyaluronic Acid (HA), and ozone in knee osteoarthritis; a one year randomized clinical trial.

Seyed Ahmad Raeissadat, Parsa Ghazi Hosseini, Mohammad Hasan Bahrami, Reza Salman Roghani, Mohammad Fathi, Azadeh Gharooee Ahangar, Mahtab Darvish

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC musculoskeletal disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07662512 (Is Intra-articular Injection of High-concentration Ozone), which is not on this map. Cited by 92 papers, 19 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed, 19 pooled it
23.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07662512 nacompletednot on this mapstarted 2023, after this paper: background citation

Is Intra-articular Injection of High-concentration Ozone (O2-O3) More Effective in Treating Knee Osteoarthritis?: A Multicenter Clinical Trial

TypeinterventionalSponsorSakarya UniversityRan2023 to 2024Enrolled159ConditionsKnee Osteoarthristis, GonarthrosisArmsozone injection
3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 19 syntheses or guidelines pooled it, 166 citations in OpenAlex.

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  13. Intra-articular injections of ozone versus hyaluronic acid for knee osteoarthritis: a level I meta-analysis.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2024
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32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Seyed Ahmad RaeissadatClinical Development Research Center of Shahid Modarres Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Parsa Ghazi HosseiniClinical Development Research Center of Shahid Modarres Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mohammad Hasan BahramiPhysical Medicine and Rehabilitation Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Reza Salman RoghaniPhysical Medicine and Rehabilitation Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mohammad FathiCritical Care Fellowship, Department of Anesthesiology, Shahid Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Azadeh Gharooee AhangarClinical Development Research Center of Shahid Modarres Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. dr.azadeh.g.ahangar@gmail.com.
Mahtab DarvishClinical Development Research Center of Shahid Modarres Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Shahid Beheshti University of Medical Sciences · IRKarolinska Institutet · SE

Funding

Vice chancellor for research, Shahid Beheshti University of Medical Sciences. IR.SBMU.MSP.REC.1396.230
6 · The paper itself

Abstract

backgroundOur study compare the short and long-term efficacy of the intra articular injections (IAIs) of hyaluronic acid (HA), platelet-rich plasma (PRP), plasma rich in growth factors (PRGF), and ozone in patients with knee osteoarthritis (OA).

methodsIn this randomized clinical trial, 238 patients with mild to moderate knee OA were randomized into 4 groups of IAIs: HA (3 doses weekly), PRP (2 doses with 3 weeks interval), PRGF (2 doses with 3 weeks interval), and Ozone (3 doses weekly). Our outcome measures were the mean changes from baseline (immediately from the first injections) until 2,6, and 12 months post intervention in scores of visual analog scale (VAS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and Lequesne index.

resultsA total of 200 patients enrolled in the final analysis. The mean age of patients was 56.9 ± 6.3 years, and 69.5% were women. In 2 months follow up, significant improvement of pain, stiffness, and function were seen in all groups compared to the baseline, but the ozone group had the best results (P < 0.05). In 6 month follow up HA, PRP, and PRGF groups demonstrated better therapeutic effects in all scores in comparison with ozone (P < 0.05). At the end of the 12th month, only PRGF and PRP groups had better results versus HA and ozone groups in all scores (P < 0.05). Despite the fact that ozone showed better early results, its effects begin to wear off earlier than other products and ultimately disappear in 12 months.

conclusionsOzone injection had rapid effects and better short-term results after 2 months, but its therapeutic effects did not persist after 6 months and at the 6-month follow up, PRP,PRGF and HA were superior to ozone. Only patients in PRP and PRGF groups improved symptoms persisted for 12 months. Therefore, these products could be the preferable choices for long-term management.

trial registrationRegistered in the Iranian Center of Clinical Trials ( www.irct.ir ) in 11/11/2017 with the following code: IRCT2017082013442N17.

Indexed as

Osteoarthritis, KneeOzonePlatelet-Rich PlasmaFemaleHumansHyaluronic AcidInjections, Intra-ArticularIntercellular Signaling Peptides and ProteinsIranMaleMiddle AgedTreatment OutcomeHyaluronic AcidIntercellular Signaling Peptides and ProteinsOzoneHyaluronic acidKnee osteoarthritisOzonePlasma rich in growth factorPlatelet rich plasma

Identifiers

PMID33536010
PMCPMC7860007
OpenAlexW3128022084

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.