Evidence map›Paper›PMID 33536245›Full record

ArticleJournal of cell science2021

Quantitative intravital imaging in zebrafish reveals

Paul J Wrighton, Arkadi Shwartz, Jin-Mi Heo, Eleanor D Quenzer, Kyle A LaBella, J Wade Harper, Wolfram Goessling

Open access · bronzeAbstract read
In one paragraph

Article in Journal of cell science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Function and regulation of the mitochondrial stress response.Nature structural & molecular biology · 2026
    Review
  4. Article
  5. Chronic exposure to low levels of glyphosate and metals induces kidney dysfunction.Toxicological sciences : an official journal of the Society of Toxicology · 2026
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Fine-tune TMEM11 to unleash basal mitophagy.The Journal of cell biology · 2023
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Paul J WrightonDivision of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-0354-0278
Arkadi ShwartzDivision of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0003-0934-5307
Jin-Mi HeoDepartment of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-6070-0592
Eleanor D QuenzerDivision of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-4951-5692
Kyle A LaBellaDivision of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-0473-9262
J Wade HarperDepartment of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-6944-7236
Wolfram GoesslingDivision of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA wgoessling@mgh.harvard.edu.ORCID 0000-0001-9972-1569
Brigham and Women's Hospital · USHarvard University · USBroad Institute · US

Funding

A Community Zebrafish Resource for Modeling GWAS BiologyR24OD017870 · OD · BRIGHAM AND WOMEN'S HOSPITAL · PI GOESSLING, WOLFRAM, MACRAE, CALUM A. · 2014 to 2021
$6.3M
Estrogen Regulation of Hepatic GrowthR01DK090311 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI GOESSLING, WOLFRAM · 2011 to 2020
$4.9M
NRSA Training CoreTL1TR003169 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI CHANDRA, JOYA, FROST, JEFFREY A. · 2019 to 2023
$3.7M
Systematic discovery and functional analysis of the PARKIN modified proteomeR37NS083524 · NINDS · HARVARD MEDICAL SCHOOL · PI HARPER, JEFFREY W · 2013 to 2019
$3.0M
Metabolic Regulation of Liver GrowthR01DK105198 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI GOESSLING, WOLFRAM · 2016 to 2020
$2.7M
Regulation of PINK1 and PARKIN-Dependent MitophagyR01NS083524 · NINDS · HARVARD MEDICAL SCHOOL · PI HARPER, JEFFREY W · 2020 to 2024
$2.2M
The role of mechanical signaling in alcoholic liver disease and hepatocellular carcinomaF32AA025271 · NIAAA · BRIGHAM AND WOMEN'S HOSPITAL · PI WRIGHTON, PAUL J. · 2016 to 2018
$174k
NCATS NIH HHS TL1 TR003169NIAAA NIH HHS F32 AA025271NIDDK NIH HHS R01 DK090311NIDDK NIH HHS R01 DK105198NIH HHS R24 OD017870NINDS NIH HHS R01 NS083524NINDS NIH HHS R37 NS083524
6 · The paper itself

Abstract

Mitophagy, the selective recycling of mitochondria through autophagy, is a crucial metabolic process induced by cellular stress, and defects are linked to aging, sarcopenia and neurodegenerative diseases. To therapeutically target mitophagy, the fundamental

Indexed as

MitophagyZebrafishAnimalsIntravital MicroscopyMitochondriaStress, PhysiologicalUbiquitin-Protein LigasesUbiquitin-Protein LigasesAutophagyFastingHypoxiaLysosomeMitochondria

Identifiers

PMID33536245
PMCPMC7929928
OpenAlexW3127762437

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.