ArticleMolecular medicine reports2021
MicroRNA‑186‑5p downregulation inhibits osteoarthritis development by targeting MAPK1.
Article in Molecular medicine reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 29 citations in OpenAlex.
- Knockdown of LINC00963 targets miR-1252-5p to reduce inflammatory levels and ECM degradation in nucleus pulposus cells of IDD.BMC musculoskeletal disorders · 2026Article
- Article
- PRKACB Attenuates Chondrocyte Loss and Inflammation in Osteoarthritis.Immunity, inflammation and disease · 2026Article
- Regulatory function of HSA-miR-186-5p on interleukin-2 expression in lumbar degenerative disc disease: a case-control study and subgroups analysis.Neurosurgical review · 2026Article
- Multi-Omics Deciphers Divergent Mechanisms in Differentially Cardiac-Remodeled Yili Horses Under Conditions of Equivalent Power Output.Animals : an open access journal from MDPI · 2025Article
- MiRNA-186 as a Biomarker of Disease Exacerbation in Rheumatoid Arthritis: Insights from Clinical Data and Molecular Marker Analysis.International journal of molecular sciences · 2025Article
- The effect of IGF-1 on cartilage injury in bone marrow mesenchymal stem cells through the BMP2-Smad1/5 signaling pathway.In vitro cellular & developmental biology. Animal · 2025Article
- Review
- Regulation of apoptosis and interaction with cartilage degeneration in osteoarthritis.Frontiers in cell and developmental biology · 2025Review
- Extracellular vesicles in osteoarthritis: mechanisms, therapeutic potential, and diagnostic applications.Frontiers in immunology · 2025Review
- Novel Clinical Insights into the Pathogenesis of Posttraumatic Elbow Stiffness: An Expression Profile Analysis of Contracted Joint Capsule in Human.Journal of inflammation research · 2025Article
- microRNA-105-5p protects against chondrocyte injury, extracellular matrix degradation, and osteoarthritis progression by targeting SPARCL1.Histology and histopathology · 2024Article
- Integration of Multi-Omics Data for the Classification of Glioma Types and Identification of Novel Biomarkers.Bioinformatics and biology insights · 2024Article
- Therapeutic potential of Coptis chinensis for arthritis with underlying mechanisms.Frontiers in pharmacology · 2023Review
- Mechanism of icariin for the treatment of osteoarthritis based on network pharmacology and molecular docking method.American journal of translational research · 2023Article
- miR-186-ANXA9 signaling inhibits tumorigenesis in breast cancer.Frontiers in oncology · 2023Article
- Circular RNA circ_0008365 regulates SOX9 by targeting miR-338-3p to inhibit IL-1β-induced chondrocyte apoptosis and extracellular matrix degradation.Journal of orthopaedic surgery and research · 2022Article
- Circ_0001174 facilitates osteosarcoma cell proliferation, migration, and invasion by targeting the miR-186-5p/MACC1 axis.Journal of orthopaedic surgery and research · 2022Article
- Hypoxia-Preconditioned Extracellular Vesicles from Mesenchymal Stem Cells Improve Cartilage Repair in Osteoarthritis.Membranes · 2022Article
- Zuogui Pill Ameliorates Glucocorticoid-Induced Osteoporosis through ZNF702P-Based ceRNA Network: Bioinformatics Analysis and Experimental Validation.Evidence-based complementary and alternative medicine : eCAM · 2022Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As a chronic degenerative joint disease, the characteristics of osteoarthritis (OA) are degeneration of articular cartilage, subchondral bone sclerosis and bone hyperplasia. It has been reported that microRNA (miR)‑186‑5p serves a key role in the development of various tumors, such as osteosarcoma, non‑small‑cell lung cancer cells, glioma and colorectal cancer. The present study aimed to investigate the effect of miR‑186‑5p in OA. Different concentrations of IL‑1β were used to treat the human chondrocyte cell line CHON‑001 to simulate inflammation, and CHON‑001 cell injury was assessed by detecting cell viability, apoptosis, caspase-3 activity and the levels of TNF‑α, IL‑8 and IL‑6. Subsequently, reverse transcription‑quantitative PCR was performed to measure miR‑186‑5p expression. The results demonstrated that following IL‑1β treatment, CHON‑001 cell viability was suppressed, apoptosis was promoted, the caspase-3 activity was significantly enhanced and the release of TNF‑α, IL‑8 and IL‑6 was increased. In addition, IL‑1β treatment significantly upregulated miR‑186‑5p expression in CHON‑001 cells. It was also identified that MAPK1 was a target gene of miR‑186‑5p, and was negatively regulated by miR‑186‑5p. miR‑186 inhibitor and MAPK1‑small interfering RNA (siRNA) were transfected into CHON‑001 cells to investigate the effect of miR‑186‑5p on CHON‑001 cell injury induced by IL‑1β. The results demonstrated that miR‑186 inhibitor suppressed the effects of IL‑1β on CHON‑001 cells, and these effects were reversed by MAPK1‑siRNA. In conclusion, the present results indicated that miR‑186‑5p could attenuate IL‑1β‑induced chondrocyte inflammation damage by increasing MAPK1 expression, suggesting that miR‑186‑5p may be used as a potential therapeutic target for OA.
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