Evidence map›Paper›PMID 33539265›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2021

Physiological and neurochemical adaptations following abrupt termination of chronic hypercapnia in goats.

Kirstyn J Buchholz, Nicholas J Burgraff, Suzanne E Neumueller, Matthew Robert Hodges, Lawrence G Pan, Hubert V Forster

Open access · greenAbstract read
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Kirstyn J BuchholzDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin.ORCID 0000-0002-2322-4811
Nicholas J BurgraffCenter for Integrated Brain Research, Seattle Children's Research Institute, Seattle, Washington.ORCID 0000-0001-7986-4247
Suzanne E NeumuellerDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin.
Matthew Robert HodgesDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin.
Lawrence G PanDepartment of Physical Therapy, Marquette University, Milwaukee, Wisconsin.
Hubert V ForsterDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin.
Medical College of Wisconsin · USMarquette University · US

Funding

INTEGRATED PHYSIOLOGY TRAINING--MOLECULE TO ORGANISMT32HL007852 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI Matthew Robert Hodges · 1996 to 2026
$6.5M
Progressive seizure-induced cardiorespiratory dysfunction in a novel mutant rat model of seizure disorderR01HL122358 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI HODGES, MATTHEW ROBERT · 2015 to 2024
$4.3M
Mechanisms of Ventilatory Adaptations to Chronic HypercapniaI01BX003284 · VA · CLEMENT J. ZABLOCKI VA MEDICAL CENTER · PI FORSTER, HUBERT V · 2016 to 2024
–
BLRD VA I01 BX003284NHLBI NIH HHS HL-007852NHLBI NIH HHS R01 HL122358NHLBI NIH HHS T32 HL007852VA BX003284
6 · The paper itself

Abstract

Chronic hypercapnia (CH) is a hallmark of respiratory diseases such as chronic obstructive pulmonary disease. In such patients, mechanical ventilation is often used to restore normal blood-gas homeostasis. However, little is known regarding physiological changes and neuroplasticity within physiological control networks after termination of CH. Utilizing our goat model of increased inspired CO

Indexed as

GoatsHypercapniaAcclimatizationAdaptation, PhysiologicalAnimalsCarbon DioxideHumansRespirationCarbon Dioxidedeacclimatizationhypercapnianeuromodulationventilatory control

Identifiers

PMID33539265
PMCPMC8262788
OpenAlexW3128104289

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.