Evidence map›Paper›PMID 33553988›Full record

ArticleJBMR plus2021

Vitamin D Receptor Mediates a Myriad of Biological Actions Dependent on Its 1,25-Dihydroxyvitamin D Ligand: Distinct Regulatory Themes Revealed by Induction of Klotho and Fibroblast Growth Factor-23.

Mark R Haussler, Sarah Livingston, Zhela L Sabir, Carol A Haussler, Peter W Jurutka

Open access · goldAbstract read
In one paragraph

Article in JBMR plus, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

  1. Etiology and Pathophysiology of Hypoparathyroidism: A Narrative Review.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022
    Pooled it
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  12. The vitamin DAmerican journal of physiology. Cell physiology · 2025
    Article
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  18. Prediagnostic 25-Hydroxyvitamin D in Association with Cancer-specific and All-cause Mortality among Low-income, Non-Hispanic Black Americans with Colorectal Cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Mark R HausslerDepartment of Basic Medical Sciences University of Arizona College of Medicine-Phoenix Phoenix AZ.ORCID https://orcid.org/0000-0002-7097-1801
Sarah LivingstonSchool of Mathematical and Natural Sciences Arizona State University Glendale AZ.
Zhela L SabirSchool of Mathematical and Natural Sciences Arizona State University Glendale AZ.
Carol A HausslerDepartment of Basic Medical Sciences University of Arizona College of Medicine-Phoenix Phoenix AZ.ORCID https://orcid.org/0000-0001-8360-3066
Peter W JurutkaDepartment of Basic Medical Sciences University of Arizona College of Medicine-Phoenix Phoenix AZ.ORCID https://orcid.org/0000-0002-4950-9161
University of Arizona · USMaricopa Community Colleges - Glendale Community College · US

Funding

Vitamin D Hormone Signaling in Bone Mineral HomeostasisR01DK033351 · NIDDK · UNIVERSITY OF ARIZONA · PI HAUSSLER, MARK R · 1986 to 2010
$2.8M
Vitamin D Status, Genetic Variation in Vitamin D Signaling and Metabolism, and RiR01CA140285 · NCI · UNIVERSITY OF ARIZONA · PI JACOBS, ELIZABETH T, JURUTKA, PETER W · 2010 to 2014
$1.5M
VITAMIN D HORMONE MECHANISM OF ACTION IN CULTURED CELLSR37DK033351 · NIDDK · UNIVERSITY OF ARIZONA · PI HAUSSLER, MARK R · 1992 to 1999
–
NCI NIH HHS R01 CA140285NIDDK NIH HHS R01 DK033351NIDDK NIH HHS R37 DK033351
6 · The paper itself

Abstract

The hormonal vitamin D metabolite, 1,25-dihydroxyvitamin D [1,25(OH)

Indexed as

BONE REMODELING/MOLECULAR PATHWAYSOSTEOBLASTSOSTEOCYTESPTH/VITAMIN D/FGF23TRANSCRIPTION FACTORS

Identifiers

PMID33553988
PMCPMC7839824
OpenAlexW3105128475

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.