Evidence map›Paper›PMID 33554390›Full record

ReviewCell proliferation2021

Magnetic fields as a potential therapy for diabetic wounds based on animal experiments and clinical trials.

Huanhuan Lv, Junyu Liu, Chenxiao Zhen, Yijia Wang, Yunpeng Wei, Weihao Ren, Peng Shang

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Cell proliferation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07729709 (Effect of Pulsed Electromagnetic Field on Chronic Anal Fissure Healing), which is not on this map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07729709 phase3completednot on this mapstarted 2026, after this paper: background citation

Effect of Pulsed Electromagnetic Field on Chronic Anal Fissure Healing: A Randomized Controlled Trial.

TypeinterventionalSponsorGalala UniversityRan2026 to 2026Enrolled100ConditionsAnal Fissure ChronicArmsPEMS, Lidocaine and general advice, Lidocaine cream and general advice
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 62 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
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  9. Review
  10. Cellular and Molecular Effects of Magnetic Fields.International journal of molecular sciences · 2024
    Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Huanhuan LvSchool of Life Sciences, Northwestern Polytechnical University, Xi'an, China.ORCID https://orcid.org/0000-0002-4869-4908
Junyu LiuSchool of Life Sciences, Northwestern Polytechnical University, Xi'an, China.
Chenxiao ZhenSchool of Life Sciences, Northwestern Polytechnical University, Xi'an, China.
Yijia WangSchool of Life Sciences, Northwestern Polytechnical University, Xi'an, China.
Yunpeng WeiResearch & Development Institute, Northwestern Polytechnical University, Shenzhen, China.
Weihao RenSchool of Life Sciences, Northwestern Polytechnical University, Xi'an, China.
Peng ShangSchool of Life Sciences, Northwestern Polytechnical University, Xi'an, China.
Northwestern Polytechnical University · CN

Funding

2019 Zhejiang Postdoctoral Science FundNational Natural Science Foundation of China 52037007National Natural Science Foundation of China 81803032Natural Science Foundation of Shaanxi Province 2019JQ632
6 · The paper itself

Abstract

Diabetes mellitus (DM) is a chronic metabolic disorder with various complications that poses a huge worldwide healthcare burden. Wounds in diabetes, especially diabetic foot ulcers (DFUs), are difficult to manage, often leading to prolonged wound repair and even amputation. Wound management in people with diabetes is an extremely clinical and social concern. Nowadays, physical interventions gain much attention and have been widely developed in the fields of tissue regeneration and wound healing. Magnetic fields (MFs)-based devices are translated into clinical practice for the treatment of bone diseases and neurodegenerative disorder. This review attempts to give insight into the mechanisms and applications of MFs in wound care, especially in improving the healing outcomes of diabetic wounds. First, we discuss the pathological conditions associated with chronic diabetic wounds. Next, the mechanisms involved in MFs' effects on wounds are explored. At last, studies and reports regarding the effects of MFs on diabetic wounds from both animal experiments and clinical trials are reviewed. MFs exhibit great potential in promoting wound healing and have been practised in the management of diabetic wounds. Further studies on the exact mechanism of MFs on diabetic wounds and the development of suitable MF-based devices could lead to their increased applications into clinical practice.

Indexed as

Magnetic FieldsAnimal ExperimentationAnimalsChronic DiseaseDiabetes MellitusDiabetic FootHumansWound Healingdiabetic foot ulcersdiabetic woundsdynamic magnetic fieldmagnetic fieldsstatic magnetic fieldwound healing

Identifiers

PMID33554390
PMCPMC7941227
OpenAlexW3128818276

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.