ReviewNutrients2021
Impact of Parenteral Lipid Emulsion Components on Cholestatic Liver Disease in Neonates.
Review in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Fish oil-containing lipid emulsions prevention on parenteral nutrition-associated cholestasis in very low birth weight infants: a meta-analysis.World journal of pediatrics : WJP · 2022Pooled it
- High Dose Fish Oil Added to Various Lipid Emulsions Normalizes Superoxide Dismutase 1 Activity in Home Parenteral Nutrition Patients.Nutrients · 2024Trial
- Association between multi-oil fat emulsion and bronchopulmonary dysplasia in preterm infants <32 weeks.Translational pediatrics · 2026Article
- Displacement of Bilirubin From Albumin by Omegaven and Intralipid.Journal of pediatric surgery · 2025Article
- Association between mixed fatty acid emulsion and parenteral nutrition-associated cholestasis in extremely low-birth-weight infants: A retrospective cohort study.JPEN. Journal of parenteral and enteral nutrition · 2025Article
- Weighing up the evidence on ethanol excipient use in common neonatal medications.Pediatric research · 2025Article
- AI-guided precision parenteral nutrition for neonatal intensive care units.Nature medicine · 2025Article
- "Calcium-Phosphorus-MagnesiumNutrients · 2025Observational
- MRPL35 Attenuates Neonatal Parenteral Nutrition-Associated Cholestasis by Modulating the ROS/JNK/NF-κB Pathway.Journal of inflammation research · 2025Article
- Review
- Parenteral Nutrition in the Pediatric Oncologic Population: Are There Any Sex Differences?Nutrients · 2023Article
- Current Insights Regarding Intestinal Failure-Associated Liver Disease (IFALD): A Narrative Review.Nutrients · 2023Review
- Pharmacologic inhibition of HNF4α prevents parenteral nutrition associated cholestasis in mice.Scientific reports · 2023Article
- Exclusive Fish Oil Lipid Emulsion Rescue Strategy Improves Cholestasis in Neonates on Partially Fish Oil-Based Lipid Emulsion: A Pilot Study.Nutrients · 2023Observational
- Partially hydrolyzed guar gum alleviates hepatic steatosis and alters specific gut microbiota in a murine liver injury model.Pediatric surgery international · 2022Article
- Marine Natural Products in Clinical Use.Marine drugs · 2022Review
- Providing the Best Parenteral Nutrition before and after Surgery for NEC: Macro and Micronutrients Intakes.Nutrients · 2022Review
- Secondary Malnutrition and Nutritional Intervention in Cholestatic Liver Diseases in Infants.Frontiers in nutrition · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Total parenteral nutrition (TPN) is a life-saving intervention for infants that are unable to feed by mouth. Infants that remain on TPN for extended periods of time are at risk for the development of liver injury in the form of parenteral nutrition associated cholestasis (PNAC). Current research suggests the lipid component of TPN is a factor in the development of PNAC. Most notably, the fatty acid composition, vitamin E concentration, and presence of phytosterols are believed key mediators of lipid emulsion driven PNAC development. New emulsions comprised of fish oil and medium chain triglycerides show promise for reducing the incidence of PNAC in infants. In this review we will cover the current clinical studies on the benefit of fish oil and medium chain triglyceride containing lipid emulsions on the development of PNAC, the current constituents of lipid emulsions that may modulate the prevalence of PNAC, and potential new supplements to TPN to further reduce the incidence of PNAC.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.