Evidence map›Paper›PMID 33557274›Full record

ArticleInternational journal of molecular sciences2021

Genomic and Epigenomic Profile of Uterine Smooth Muscle Tumors of Uncertain Malignant Potential (STUMPs) Revealed Similarities and Differences with Leiomyomas and Leiomyosarcomas.

Donatella Conconi, Serena Redaelli, Andrea Alberto Lissoni, Chiara Cilibrasi, Patrizia Perego, Eugenio Gautiero, Elena Sala, Mariachiara Paderno, Leda Dalprà, Fabio Landoni and 3 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Insights into the Peritumoural Brain Zone of Glioblastoma:International journal of molecular sciences · 2023
    Article
  7. Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Donatella ConconiSchool of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.ORCID 0000-0001-5665-9558
Serena RedaelliSchool of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.ORCID 0000-0003-0415-4085
Andrea Alberto LissoniSchool of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.
Chiara CilibrasiDepartment of Biochemistry and Biomedicine, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9RH, UK.
Patrizia PeregoDivision of Pathology, San Gerardo Hospital, 20900 Monza, Italy.
Eugenio GautieroMedical Genetics Laboratory, San Gerardo Hospital, 20900 Monza, Italy.
Elena SalaMedical Genetics Laboratory, San Gerardo Hospital, 20900 Monza, Italy.
Mariachiara PadernoSchool of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.
Leda DalpràSchool of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.
Fabio LandoniSchool of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.
Marialuisa LavitranoSchool of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.ORCID 0000-0003-4852-1318
Gaia RoversiSchool of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.
Angela BentivegnaSchool of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.ORCID 0000-0001-7535-846X

Funding

Università degli Studi di Milano-Bicocca 2016-ATE-0511
6 · The paper itself

Abstract

Uterine smooth muscle tumors of uncertain malignant potential (STUMPs) represent a heterogeneous group of tumors that cannot be histologically diagnosed as unequivocally benign or malignant. For this reason, many authors are working to obtain a better definition of diagnostic and prognostic criteria. In this work, we analyzed the genomic and epigenomic profile of uterine smooth muscle tumors (USMTs) in order to find similarities and differences between STUMPs, leiomyosarcomas (LMSs) and leiomyomas (LMs), and possibly identify prognostic factors in this group of tumors. Array-CGH data on 23 USMTs demonstrated the presence of a more similar genomic profile between STUMPs and LMSs. Some genes, such as

Indexed as

EpigenomicsGene Expression Regulation, NeoplasticAdultAgedBiomarkers, TumorCase-Control StudiesDNA MethylationFemaleFollow-Up StudiesGenomicsHumansLeiomyomaLeiomyosarcomaMiddle AgedPrognosisSmooth Muscle TumorBiomarkers, Tumorarray-CGHcopy number alterationsGenome Wide DNA Methylationuterine STUMP

Identifiers

PMID33557274
PMCPMC7914585

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.