Evidence map›Paper›PMID 33563785›Full record

ArticlemSystems2021

Manipulation of IRE1-Dependent MAPK Signaling by a Vibrio Agonist-Antagonist Effector Pair.

Nicole J De Nisco, Amanda K Casey, Mohammed Kanchwala, Alexander E Lafrance, Fatma S Coskun, Lisa N Kinch, Nick V Grishin, Chao Xing, Kim Orth

Open access · goldAbstract read
In one paragraph

Article in mSystems, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. AMPylation: key roles in biological regulation across prokaryotes and eukaryotes.Frontiers in cellular and infection microbiology · 2026
    Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Bacterial Toxin and Effector Regulation of Intestinal Immune Signaling.Frontiers in cell and developmental biology · 2022
    Review
  7. Comparative Metabolomics and Proteomics RevealFrontiers in immunology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Nicole J De Nisco *Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.ORCID https://orcid.org/0000-0002-7670-5301
Amanda K Casey *Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.ORCID https://orcid.org/0000-0002-5829-748X
Mohammed KanchwalaMcDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Alexander E LafranceDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Fatma S CoskunDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Lisa N KinchHoward Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Nick V GrishinHoward Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Chao XingMcDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Kim OrthDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA kim.orth@utsouthwestern.edu.ORCID https://orcid.org/0000-0002-0678-7620
Howard Hughes Medical Institute · USThe University of Texas Southwestern Medical Center · USSouthwestern Medical Center · US

Funding

UT Southwestern Center for Translational Medicine (UL1/KL2/TL1)UL1TR001105 · NCATS · UT SOUTHWESTERN MEDICAL CENTER · PI TOTO, ROBERT DANIEL · 2013 to 2017
$24.5M
Biochemical Characterization of Yersinia Effector YopJ.R01AI056404 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI ORTH, KIM · 2003 to 2012
$2.8M
Biochemistry, biology and diversity of Fic domainsR35GM134945 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI ORTH, KIM · 2020 to 2024
$1.8M
Computational analysis of proteinsR35GM127390 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI GRISHIN, NICK V. · 2018 to 2022
$1.5M
Proteostasis, AMPylation and the Unfolded Protein repsonse (UPR)R01GM115188 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI ORTH, KIM · 2015 to 2018
$1.2M
NCATS NIH HHS UL1 TR001105NIAID NIH HHS R01 AI056404NIGMS NIH HHS R01 GM115188NIGMS NIH HHS R35 GM127390NIGMS NIH HHS R35 GM134945
6 · The paper itself

Abstract

Diverse bacterial pathogens employ effector delivery systems to disrupt vital cellular processes in the host (N. M. Alto and K. Orth, Cold Spring Harbor Perspect Biol 4:a006114, 2012, https://doi.org/10.1101/cshperspect.a006114). The type III secretion system 1 of the marine pathogen

Indexed as

effectorErkIre1T3SSUPRV-ATPaseVibrio parahaemolyticus

Identifiers

PMID33563785
PMCPMC7883537
OpenAlexW3126165798

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.