Evidence map›Paper›PMID 33564174›Full record

ReviewNature reviews. Microbiology2021

Cells within cells: Rickettsiales and the obligate intracellular bacterial lifestyle.

Jeanne Salje

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
106citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

106 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Tick cells as a tractable arthropod model for studyingApplied and environmental microbiology · 2026
    Article
  7. Evolutionary innovation through fusion of sequences from across the tree of life.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  8. Review
  9. Article
  10. Article
  11. Assessment of the Pathogenicity ofPathogens (Basel, Switzerland) · 2026
    Article
  12. Facultative mutualism betweenISME communications · 2026
    Article
  13. EvaluatingFrontiers in microbiology · 2026
    Article
  14. Diversity of Bacteria.Progress in molecular and subcellular biology · 2026
    Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article

46 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Jeanne SaljeCentre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK. jeanne.salje@ndm.ox.ac.uk.ORCID http://orcid.org/0000-0001-5802-4580

Funding

Metabolic quiescence and latent infection in Orientia tsutsugamushiR56AI148645 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI SALJE, JEANNE · 2020 to 2020
$471k
The basis of strain-specific differences in virulence in the human pathogen Orientia tsutsugamushiR21AI144385 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI SALJE, JEANNE · 2020 to 2021
$430k
NIAID NIH HHS R21 AI144385NIAID NIH HHS R56 AI148645
6 · The paper itself

Abstract

The Rickettsiales are a group of obligate intracellular vector-borne Gram-negative bacteria that include many organisms of clinical and agricultural importance, including Anaplasma spp., Ehrlichia chaffeensis, Wolbachia, Rickettsia spp. and Orientia tsutsugamushi. This Review provides an overview of the current state of knowledge of the biology of these bacteria and their interactions with host cells, with a focus on pathogenic species or those that are otherwise important for human health. This includes a description of rickettsial genomics, bacterial cell biology, the intracellular lifestyles of Rickettsiales and the mechanisms by which they induce and evade the innate immune response.

Indexed as

Bacterial Physiological PhenomenaGenome, BacterialHumansPhylogenyRickettsiales

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.