Evidence map›Paper›PMID 33565964›Full record

ArticleeLife2021

Perinatal granulopoiesis and risk of pediatric asthma.

Benjamin A Turturice, Juliana Theorell, Mary Dawn Koenig, Lisa Tussing-Humphreys, Diane R Gold, Augusto A Litonjua, Emily Oken, Sheryl L Rifas-Shiman, David L Perkins, Patricia W Finn

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Benjamin A TurturiceDepartment of Microbiology and Immunology, University of Illinois, Chicago, United States.ORCID 0000-0001-9382-4612
Juliana TheorellDepartment of Medicine, Division of Pulmonary, Critical Care, Sleep, and Allergy, University of Illinois, Chicago, United States.
Mary Dawn KoenigDepartment of Women, Children and Family Health Science, College of Nursing, University of Illinois, Chicago, United States.
Lisa Tussing-HumphreysDepartment of Medicine and Cancer Center, University of Illinois, Chicago, United States.
Diane R GoldChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States.
Augusto A LitonjuaDivision of Pulmonary Medicine, Department of Pediatrics, University of Rochester, Rochester, United States.
Emily OkenDivision of Chronic Disease Research Across the Life Course, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, United States.
Sheryl L Rifas-ShimanDivision of Chronic Disease Research Across the Life Course, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, United States.
David L PerkinsDepartment of Medicine, Division of Nephrology, University of Illinois, Chicago, United States.
Patricia W FinnDepartment of Microbiology and Immunology, University of Illinois, Chicago, United States.
University of Illinois Urbana-Champaign · USHarvard University · USUniversity of Illinois Chicago · USBrigham and Women's Hospital · USUniversity of Rochester · US

Funding

VISUAL INDICES OF NEUROTOXICITYP30ES001247 · NIEHS · UNIVERSITY OF ROCHESTER · PI Martha Susiarjo · 1985 to 2026
$42.8M
Prenatal environmental determinants of health in young adulthood: a lifecourse approachR01HD034568 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI Marie-France Hivert, Emily Oken · 1998 to 2026
$20.6M
Common and distinct early environmental influences on cardiometabolic and respiratory health: Mechanisms and methodsUH3OD023286 · OD · HARVARD PILGRIM HEALTH CARE, INC. · PI OKEN, EMILY · 2018 to 2022
$11.7M
The Fetal and Childhood Environment, Oxidative Balance, Inflammation and AsthmaR01AI102960 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI GOLD, DIANE R, OKEN, EMILY · 2013 to 2017
$4.0M
Pulmonary Interactions with Innate ImmunityR01AI053878 · NIAID · UNIVERSITY OF ILLINOIS AT CHICAGO · PI FINN, PATRICIA W, PERKINS, DAVID LINN · 2004 to 2013
$4.0M
Perinatal Origins of AsthmaF30HL136001 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI TURTURICE, BENJAMIN · 2017 to 2020
$192k
National Institute of Allergy and Infectious Diseases R01AI053878NHLBI NIH HHS F30 HL136001NIAID NIH HHS R01 AI053878NIAID NIH HHS R01 AI102960NICHD NIH HHS R01 HD034568NIEHS NIH HHS P30 ES001247NIH HHS UH3 OD023286
6 · The paper itself

Abstract

There are perinatal characteristics, such as gestational age, reproducibly associated with the risk for pediatric asthma. Identification of biologic processes influenced by these characteristics could facilitate risk stratification or new therapeutic targets. We hypothesized that transcriptional changes associated with multiple epidemiologic risk factors would be mediators of pediatric asthma risk. Using publicly available transcriptomic data from cord blood mononuclear cells, transcription of genes involved in myeloid differentiation was observed to be inversely associated with a pediatric asthma risk stratification based on multiple perinatal risk factors. This gene signature was validated in an independent prospective cohort and was specifically associated with genes localizing to neutrophil-specific granules. Further validation demonstrated that umbilical cord blood serum concentration of PGLYRP-1, a specific granule protein, was inversely associated with mid-childhood current asthma and early-teen FEV

Indexed as

Risk FactorsAdolescentAsthmaChildChild, PreschoolFemaleFetal BloodGestational AgeHumansInfantMaleProspective Studiesallergyasthmafetal bloodgranulocyteshumanimmunologyinflammationmedicinepeptidoglycan recognition proteinrisk factor

Identifiers

PMID33565964
PMCPMC7889076
OpenAlexW3127588190

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.