Evidence map›Paper›PMID 33569381›Full record

ArticleFrontiers in cell and developmental biology2020

miRNA and mRNA Profiling Links Connexin Deficiency to Deafness via Early Oxidative Damage in the Mouse

Giulia Gentile, Fabiola Paciello, Veronica Zorzi, Antonio Gianmaria Spampinato, Maria Guarnaccia, Giulia Crispino, Abraham Tettey-Matey, Ferdinando Scavizzi, Marcello Raspa, Anna Rita Fetoni and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Recent Progress in Mechanism-Based Therapies forInternational journal of molecular sciences · 2026
    Review
  2. Perspective and Therapeutic Potential of the Noncoding RNA-Connexin Axis.International journal of molecular sciences · 2024
    Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Giulia GentileDepartment of Biomedical Sciences, National Research Council (CNR) Institute for Biomedical Research and Innovation, Catania, Italy.
Fabiola PacielloDepartment of Neuroscience, Università Cattolica del Sacro Cuore, Rome, Italy.
Veronica ZorziDepartment of Head and Neck Surgery, Università Cattolica del Sacro Cuore, Rome, Italy.
Antonio Gianmaria SpampinatoDepartment of Biomedical Sciences, National Research Council (CNR) Institute for Biomedical Research and Innovation, Catania, Italy.
Maria GuarnacciaDepartment of Biomedical Sciences, National Research Council (CNR) Institute for Biomedical Research and Innovation, Catania, Italy.
Giulia CrispinoDepartment of Biomedical Sciences, National Research Council (CNR) Institute of Biochemistry and Cell Biology, Rome, Italy.
Abraham Tettey-MateyDepartment of Biomedical Sciences, National Research Council (CNR) Institute of Biochemistry and Cell Biology, Rome, Italy.
Ferdinando ScavizziDepartment of Biomedical Sciences, National Research Council (CNR) Institute of Biochemistry and Cell Biology, Rome, Italy.
Marcello RaspaFondazione Policlinico Universitario A. Gemelli Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
Anna Rita FetoniFondazione Policlinico Universitario A. Gemelli Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
Sebastiano CavallaroDepartment of Biomedical Sciences, National Research Council (CNR) Institute for Biomedical Research and Innovation, Catania, Italy.
Fabio MammanoDepartment of Biomedical Sciences, National Research Council (CNR) Institute of Biochemistry and Cell Biology, Rome, Italy.
National Research Council · ITInstitute of Cell Biology and Neurobiology · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITUniversità Cattolica del Sacro Cuore · ITInstitute for Biomedical Research and Innovation · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pathogenic mutations in the non-syndromic hearing loss and deafness 1 (DFNB1) locus are the primary cause of monogenic inheritance for prelingual hearing loss. To unravel molecular pathways involved in etiopathology and look for early degeneration biomarkers, we used a system biology approach to analyze Cx30

Indexed as

connexinsearly degenerationhearing lossmolecular pathway analysisoxidative stresspost-natal developmentsystems biologyvascular dysfunction

Identifiers

PMID33569381
PMCPMC7868390
OpenAlexW3122085107

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.