Evidence map›Paper›PMID 33569424›Full record

ArticleAnnals of translational medicine2021

Maternally expressed 3 protects the intestinal barrier from cardiac arrest-induced ischemia/reperfusion injury via miR-34a-3p/sirtuin 1/nuclear factor kappa B signaling.

Xianwei Huang, Mandong Pan, Penghui Du, Yinrong Chen, Caixia Zhang, Wang Lu, Jiyan Lin

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Xianwei HuangEmergency Department, The First Affiliated Hospital of Xiamen University, Xiamen, China.
Mandong PanEmergency Department, The First Affiliated Hospital of Xiamen University, Xiamen, China.
Penghui DuEmergency Department, The First Affiliated Hospital of Xiamen University, Xiamen, China.
Yinrong ChenEmergency Department, The First Affiliated Hospital of Xiamen University, Xiamen, China.
Caixia ZhangEmergency Department, The First Affiliated Hospital of Xiamen University, Xiamen, China.
Wang LuEmergency Department, The First Affiliated Hospital of Xiamen University, Xiamen, China.
Jiyan LinEmergency Department, The First Affiliated Hospital of Xiamen University, Xiamen, China.
First Affiliated Hospital of Xiamen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCardiac arrest (CA), a common disease with a high mortality rate, is a leading cause of ischemia/reperfusion (I/R)-induced dysfunction of the intestinal barrier. Long non-coding RNAs (lncRNAs) play crucial roles in multiple pathological processes. However, the effect of the lncRNA maternally expressed 3 (MEG3) on intestinal I/R injury and the intestinal barrier has not been fully determined. Therefore, this study aimed to investigate the function of MEG3 in CA-induced intestinal barrier dysfunction.

methodsThe oxygen and glucose deprivation (OGD) model in the human colorectal adenocarcinoma Caco-2 cells and

resultsInterestingly, we found that MEG3 could protect Caco-2 cells from oxygen-glucose deprivation (OGD)/reoxygenation-induced I/R injury by modulating cell proliferation and apoptosis. Moreover, MEG3 relieved OGD-induced intestinal barrier dysfunction

conclusionsLncRNA MEG3 can protect the intestinal barrier from cardiac arrest-induced I/R injury via miR-34a-3p/SIRT1/NF-κB signaling. This finding provides new insight into the mechanism by which MEG3 restores intestinal barrier function following I/R injury, presenting it as a potential therapeutic candidate or strategy in intestinal injury.

Indexed as

Cardiac arrest (CA)intestinal barrierlncRNA MEG3miR-34a-3pnuclear factor kappa B (NF-κB)sirtuin1 (SIRT1)

Identifiers

PMID33569424
PMCPMC7867908
OpenAlexW3121140318

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.