Evidence map›Paper›PMID 33570461›Full record

ReviewPhysiological reviews2021

Carotid body chemoreceptors: physiology, pathology, and implications for health and disease.

Rodrigo Iturriaga, Julio Alcayaga, Mark W Chapleau, Virend K Somers

Open access · greenAbstract readReview
In one paragraph

Review in Physiological reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
103citing papers in PubMed, 1 pooled it
11.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

103 citing papers in PubMed, 1 synthesis or guideline pooled it, 175 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Gefapixant as a P2X3 receptor antagonist treatment for obstructive sleep apnea: a randomized controlled trial.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024
    Trial
  5. Review
  6. Article
  7. Article
  8. Acute Hypoxia Inhibits KActa physiologica (Oxford, England) · 2026
    Article
  9. Review
  10. Sleep, Neural Circulatory Control, and Cardiovascular Disease: A Mechanistic Review.Arteriosclerosis, thrombosis, and vascular biology · 2026
    Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Review

43 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 2 countries.

Rodrigo IturriagaLaboratorio de Neurobiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile, and Centro de Excelencia en Biomedicina de Magallanes, Universidad de Magallanes, Punta Arenas, Chile.
Julio AlcayagaLaboratorio de Fisiología Celular, Facultad de Ciencias, Universidad de Chile, Santiago, Chile.
Mark W ChapleauDepartment of Internal Medicine, University of Iowa and Department of Veterans Affairs Medical Center, Iowa City, Iowa.
Virend K SomersDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota.
Mayo Clinic · USUniversidad de Magallanes · CLUniversity of Chile · CLUniversity of Iowa · US

Funding

VASOPRESSIN IN CARDIOVASCULAR REGULATIONP01HL014388 · NHLBI · UNIVERSITY OF IOWA · PI SANFORD, L PHILLIP · 1985 to 2018
$40.3M
Disease Mechanisms in Sleep ApneaR01HL065176 · NHLBI · MAYO CLINIC ROCHESTER · PI SOMERS, VIREND K · 1999 to 2021
$5.8M
Sleep Apnea and Hypertrophic Cardiomyopathy - Implications for Arrhythmia and Sudden DeathR01HL134885 · NHLBI · MAYO CLINIC ROCHESTER · PI SOMERS, VIREND K · 2017 to 2020
$3.0M
NHLBI NIH HHS P01 HL014388NHLBI NIH HHS R01 HL065176NHLBI NIH HHS R01 HL134885
6 · The paper itself

Abstract

The carotid body (CB) is the main peripheral chemoreceptor for arterial respiratory gases O

Indexed as

AnimalsAutonomic Nervous SystemCardiovascular SystemCarotid BodyChemoreceptor CellsHumansHypoxiaautonomic systemcarotid bodyhypoxia

Identifiers

PMID33570461
PMCPMC8526340
OpenAlexW3127166110

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.