Evidence map›Paper›PMID 33571449›Full record

ArticleCell host & microbe2021

HIV-infected macrophages resist efficient NK cell-mediated killing while preserving inflammatory cytokine responses.

Kiera L Clayton, Geetha Mylvaganam, Alonso Villasmil-Ocando, Heather Stuart, Marcela V Maus, Mohammad Rashidian, Hidde L Ploegh, Bruce D Walker

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell host & microbe, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 55 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Kiera L ClaytonRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Geetha MylvaganamRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
Alonso Villasmil-OcandoRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Heather StuartRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Marcela V MausMassachusetts General Hospital, Boston, MA 02114, USA.
Mohammad RashidianDana-Farber Cancer Institute, Boston, MA 02215, USA; Boston Children's Hospital, Boston, MA 02115, USA.
Hidde L PloeghBoston Children's Hospital, Boston, MA 02115, USA; Department of Immunology, Harvard Medical School, Boston, MA 02115, USA.
Bruce D WalkerRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA; Massachusetts General Hospital, Boston, MA 02114, USA; Department of Immunology, Harvard Medical School, Boston, MA 02115, USA; Institute of Medical Engineering and Sciences and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02138, USA. Electronic address: bwalker@mgh.harvard.edu.
Ragon Institute of MGH, MIT and Harvard · USBoston Children's Hospital · USHoward Hughes Medical Institute · USMassachusetts General Hospital · US

Funding

The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI RAJESH T GANDHI · 2004 to 2026
$94.4M
Molecular networks of HIV-specific CD4 T cell help to B cellsR01AI118544 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI WALKER, BRUCE D · 2015 to 2019
$2.2M
Understanding and Reversing T Cell Dysfunction to Control and Eliminate Persistent HIV ReservoirsR01AI149704 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI WALKER, BRUCE D · 2020 to 2024
$2.1M
Characterization of CD8+ T cell killer activity and the mechanisms responsible for detachment from dead target cellsF32AI143480 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI CLAYTON, KIERA L. · 2019 to 2020
$133k
NIAID NIH HHS F32 AI143480NIAID NIH HHS P30 AI060354NIAID NIH HHS R01 AI118544NIAID NIH HHS R01 AI149704
6 · The paper itself

Abstract

Natural killer (NK) cells are innate cytolytic effectors that target HIV-infected CD4

Indexed as

Antibody-Dependent Cell CytotoxicityCD4-Positive T-LymphocytesCytokinesHIV-1HIV AntibodiesHIV InfectionsHumansKiller Cells, NaturalMacrophagesCytokinesHIV AntibodiesADCCCAR T cellsHIVHIV envelopemacrophageNK cellsvirus-containing compartment

Identifiers

PMID33571449
PMCPMC8486985
OpenAlexW3126149671

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.