Evidence map›Paper›PMID 33572349›Full record

ArticleCancers2021

Melanotic Neuroectodermal Tumor of Infancy (MNTI) and Pineal Anlage Tumor (PAT) Harbor A Medulloblastoma Signature by DNA Methylation Profiling.

Oscar Lopez-Nunez, Rita Alaggio, Ivy John, Andrea Ciolfi, Lucia Pedace, Angela Mastronuzzi, Francesca Gianno, Felice Giangaspero, Sabrina Rossi, Vittoria Donofrio and 5 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06878469 (SIMPLIF-AI), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06878469 narecruitingnot on this mapstarted 2025, after this paper: background citation

SIMPLIF-AI: SIMPLIFication and Standardization of Care Pathways for Patients With Rare Brain Tumors Through Artificial Intelligence

TypeinterventionalSponsorFondazione I.R.C.C.S. Istituto Neurologico Carlo BestaRan2025 to 2027Enrolled200ConditionsBrain TumorsArmsRehaCom
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. A 5-month-old infant with a pineal tumor.Brain pathology (Zurich, Switzerland) · 2026
    Article
  2. Histopathology and Molecular Pathology of Pineal Region Tumors.Advances and technical standards in neurosurgery · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Histopathology and molecular pathology of pediatric pineal parenchymal tumors.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023
    Review
  7. Pineal anlage tumor: a case report and the literature review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023
    Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 2 countries.

Oscar Lopez-NunezDivision of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.ORCID 0000-0002-3649-3885
Rita AlaggioPathology Unit, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Ivy JohnDepartment of Pathology and Laboratory Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.ORCID 0000-0002-4751-7678
Andrea CiolfiGenetics and Rare Diseases Research Division, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Lucia PedaceDepartment of Pediatric Onco-Hematology and Cell and Gene Therapy, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Angela MastronuzziDepartment of Pediatric Onco-Hematology and Cell and Gene Therapy, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.ORCID 0000-0002-4408-2373
Francesca GiannoRadiologic, Oncologic and Anatomo-Pathological Sciences Department, Sapienza University, 00161 Rome, Italy.ORCID 0000-0002-6223-9952
Felice GiangasperoRadiologic, Oncologic and Anatomo-Pathological Sciences Department, Sapienza University, 00161 Rome, Italy.ORCID 0000-0001-5382-2380
Sabrina RossiPathology Unit, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.ORCID 0000-0002-1477-8855
Vittoria DonofrioPathology Unit, Azienda Ospedaliera Santobono-Pausilipon, 80122 Naples, Italy.
Giuseppe CinalliPathology Unit, Azienda Ospedaliera Santobono-Pausilipon, 80122 Naples, Italy.ORCID 0000-0002-7797-8483
Lea F SurreyDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-6944-2232
Marco TartagliaGenetics and Rare Diseases Research Division, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Franco LocatelliDepartment of Pediatric Onco-Hematology and Cell and Gene Therapy, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Evelina MieleDepartment of Pediatric Onco-Hematology and Cell and Gene Therapy, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.ORCID 0000-0002-4747-1032
Bambino Gesù Children's Hospital · ITCincinnati Children's Hospital Medical Center · USIstituto Neurologico Mediterraneo · ITSapienza University of Rome · ITUniversity of Pennsylvania · USUniversity of Pittsburgh Medical Center · US

Funding

Italian Ministry of Health N/AThe Children's Hospital of Philadelphia, Department of Pathology N/AUniversity of Pittsburgh Medical Center, Department of Pathology Research Funds N/A
6 · The paper itself

Abstract

MNTI is a rare tumor of indeterminate histogenesis and molecular signature. We performed methylation and copy number variation (CNV) profiles in patients with MNTI (

Indexed as

copy number variationDNA methylationmedulloblastomamelanotic neuroectodermal tumormelanotic progonomapineal anlage tumor

Identifiers

PMID33572349
PMCPMC7916108
OpenAlexW3127518351

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.