ReviewMolecules (Basel, Switzerland)2021
Applications of Vibrational Spectroscopy for Analysis of Connective Tissues.
Review in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- New insights on collagen structural organization and spatial distribution around dental implants: a comparison between machined and laser-treated surfaces.Journal of translational medicine · 2024Trial
- Skin keratin correlates with bone and tendon collagen quality: a proof-of-concept clinical study using FTIR spectroscopy in shoulder arthroplasty patients.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2026Article
- Bioinspired and living multiscale composites for regenerative medicine in the treatment of surgical site infections.Journal of nanobiotechnology · 2026Review
- Shedding Light on the Past: Temporal Classification of Zoological Specimens from Museum Collections with Portable NIR Sensors and Multivariate Error Modeling.Analytical chemistry · 2026Article
- Biomolecule-functionalized dental implant surfaces: Towards augmenting soft tissue integration.Bioactive materials · 2025Review
- The Multifactorial Relationship Between Bone Tissue Water and Stiffness at the Proximal Femur.Calcified tissue international · 2025Article
- Assessment of submicron bone tissue composition in plastic-embedded samples using optical photothermal infrared (O-PTIR) spectral imaging and machine learning.Journal of structural biology: X · 2024Article
- From Structure to Strength: Analyzing the Impact of Sulfuric Acid on Pig Bone Demineralization Through FTIR, LIBS, and AAS.International journal of molecular sciences · 2024Article
- Rapid Hyperspectral Photothermal Mid-Infrared Spectroscopic Imaging from Sparse Data for Gynecologic Cancer Tissue Subtyping.Analytical chemistry · 2024Article
- Multi-branch attention Raman network and surface-enhanced Raman spectroscopy for the classification of neurological disorders.Biomedical optics express · 2024Article
- Article
- Visible and Near-Infrared Spectroscopy Enables Differentiation of Normal and Early Osteoarthritic Human Knee Joint Articular Cartilage.Annals of biomedical engineering · 2023Article
- Corneal Wound Healing in the Presence of Antifibrotic Antibody Targeting Collagen Fibrillogenesis: A Pilot Study.International journal of molecular sciences · 2023Article
- Loss of function mutation in Ank causes aberrant mineralization and acquisition of osteoblast-like-phenotype by the cells of the intervertebral disc.Cell death & disease · 2023Article
- A Study of the Peculiarities of the Formation of a Hybrid Interface Based on Polydopamine between Dental Tissues and Dental Composites, Using IR and Raman Microspectroscopy, at the Submicron Level.International journal of molecular sciences · 2023Article
- Characterisation of Cartilage Damage via Fusing Mid-Infrared, Near-Infrared, and Raman Spectroscopic Data.Journal of personalized medicine · 2023Article
- Article
- Characterization of Different Types of Epiretinal Proliferations by Synchrotron Radiation-Based Fourier Transform Infrared Micro-Spectroscopy.International journal of molecular sciences · 2023Article
- The Impact of Acetic Acid on Measuring Ethanol Concentrations in Water and Human Serum Using Short-Wave Infrared Spectroscopy.International journal of molecular sciences · 2023Article
- Application of Vibrational Spectroscopic Techniques in the Study of the Natural Polysaccharides and Their Cross-Linking Process.International journal of molecular sciences · 2023Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Advances in vibrational spectroscopy have propelled new insights into the molecular composition and structure of biological tissues. In this review, we discuss common modalities and techniques of vibrational spectroscopy, and present key examples to illustrate how they have been applied to enrich the assessment of connective tissues. In particular, we focus on applications of Fourier transform infrared (FTIR), near infrared (NIR) and Raman spectroscopy to assess cartilage and bone properties. We present strengths and limitations of each approach and discuss how the combination of spectrometers with microscopes (hyperspectral imaging) and fiber optic probes have greatly advanced their biomedical applications. We show how these modalities may be used to evaluate virtually any type of sample (ex vivo, in situ or in vivo) and how "spectral fingerprints" can be interpreted to quantify outcomes related to tissue composition and quality. We highlight the unparalleled advantage of vibrational spectroscopy as a label-free and often nondestructive approach to assess properties of the extracellular matrix (ECM) associated with normal, developing, aging, pathological and treated tissues. We believe this review will assist readers not only in better understanding applications of FTIR, NIR and Raman spectroscopy, but also in implementing these approaches for their own research projects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.