Evidence map›Paper›PMID 33572630›Full record

ArticleNutrients2021

Hypothalamic Renin-Angiotensin System and Lipid Metabolism: Effects of Virgin Olive Oil versus Butter in the Diet.

Ana Belén Segarra, Germán Domínguez-Vías, José Redondo, Magdalena Martínez-Cañamero, Manuel Ramírez-Sánchez, Isabel Prieto

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Ana Belén SegarraUnit of Physiology, Department of Health Sciences, University of Jaén, Las Lagunillas, 23071 Jaén, Spain.ORCID 0000-0002-9409-6052
Germán Domínguez-VíasDepartment of Physiology, Faculty of Health Sciences, Ceuta, University of Granada, 18071 Granada, Spain.ORCID 0000-0002-9546-9148
José RedondoUnit of Physiology, Department of Health Sciences, University of Jaén, Las Lagunillas, 23071 Jaén, Spain.
Magdalena Martínez-CañameroUnit of Microbiology, Department of Health Sciences, University of Jaén, Las Lagunillas, 23071 Jaén, Spain.ORCID 0000-0003-3241-0066
Manuel Ramírez-SánchezUnit of Physiology, Department of Health Sciences, University of Jaén, Las Lagunillas, 23071 Jaén, Spain.
Isabel PrietoUnit of Physiology, Department of Health Sciences, University of Jaén, Las Lagunillas, 23071 Jaén, Spain.ORCID 0000-0003-0624-9504
Universidad de Jaén · ESUniversidad de Granada · ES

Funding

Universidad de Jaén PP2009/13/03
6 · The paper itself

Abstract

The brain renin-angiotensin system (RAS) has been recently involved in the homeostatic regulation of energy. Our goal was to analyse the influence of a diet rich in saturated fatty acids (butter) against one enriched in monounsaturated fatty acids (olive oil) on hypothalamic RAS, and their relationship with the metabolism of fatty acids. Increases in body weight and visceral fat, together with an increase in aminopeptidase A expression and reductions in AngII and AngIV were observed in the hypothalamus of animals fed with the butter diet. In this group, a marked reduction in the expression of genes related to lipid metabolism (LPL, CD36, and CPT-1) was observed in liver and muscle. No changes were found in terms of body weight, total visceral fat and the expression of hepatic genes related to fatty acid metabolism in the olive oil diet. The expressions of LPL and CD36 were reduced in the muscles, although the decrease was lower than in the butter diet. At the same time, the fasting levels of leptin were reduced, no changes were observed in the hypothalamic expression of aminopeptidase A and decreases were noted in the levels of AngII, AngIV and AngIII. These results support that the type of dietary fat is able to modify the hypothalamic profile of RAS and the body energy balance, related to changes in lipid metabolism.

Indexed as

ButterLipid MetabolismAngiotensin IIAngiotensin IIIAnimalsBody WeightCD36 AntigensDiet, High-FatEnergy MetabolismFastingGene ExpressionGlutamyl AminopeptidaseHypothalamusIntra-Abdominal FatLeptinLipoprotein LipaseAngiotensin IIangiotensin II, des-Asp(1)-des-Arg(2)-Ile(5)-Angiotensin IIIButterCD36 AntigensCd36 protein, mouseGlutamyl AminopeptidaseLeptinLipoprotein LipaseOlive OilRNA, Messengerbrain renin–angiotensin systemenergy balancefatty acid metabolismvirgin olive oil

Identifiers

PMID33572630
PMCPMC7912484
OpenAlexW3126302240

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.