Evidence map›Paper›PMID 33573164›Full record

ReviewNutrients2021

Magnesium in Aging, Health and Diseases.

Mario Barbagallo, Nicola Veronese, Ligia J Dominguez

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07515417 (Effect of Magnesium Supplementation on Sleep Quality and Cognition in Saudi Adults), which is not on this map. Cited by 168 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
168citing papers in PubMed, 8 pooled it
28.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07515417 nacompletednot on this mapstarted 2024, after this paper: background citation

Effect of Magnesium Supplementation on Sleep Quality and Cognition in Saudi Adults: A Randomized Controlled Trial

TypeinterventionalSponsorUmm Al-Qura UniversityRan2024 to 2026Enrolled41ConditionsHealthy, Health Adult Subjects, Healthy Participants, Healthy Adult ParticipantsArmsMagnesium 400Mg
3 · Its place in the literature

Who cites it

168 citing papers in PubMed, 8 syntheses or guidelines pooled it, 339 citations in OpenAlex.

  1. Pooled it
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  9. The effects of magnesium L-threonate (MagteinFrontiers in nutrition · 2025
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108 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Mario BarbagalloGeriatric Unit, Department of Medicine, University of Palermo, 90127 Palermo, Italy.ORCID 0000-0002-1349-6530
Nicola VeroneseGeriatric Unit, Department of Medicine, University of Palermo, 90127 Palermo, Italy.
Ligia J DominguezGeriatric Unit, Department of Medicine, University of Palermo, 90127 Palermo, Italy.
University of Palermo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several changes of magnesium (Mg) metabolism have been reported with aging, including diminished Mg intake, impaired intestinal Mg absorption and renal Mg wasting. Mild Mg deficits are generally asymptomatic and clinical signs are usually non-specific or absent. Asthenia, sleep disorders, hyperemotionality, and cognitive disorders are common in the elderly with mild Mg deficit, and may be often confused with age-related symptoms. Chronic Mg deficits increase the production of free radicals which have been implicated in the development of several chronic age-related disorders. Numerous human diseases have been associated with Mg deficits, including cardiovascular diseases, hypertension and stroke, cardio-metabolic syndrome and type 2 diabetes mellitus, airways constrictive syndromes and asthma, depression, stress-related conditions and psychiatric disorders, Alzheimer's disease (AD) and other dementia syndromes, muscular diseases (muscle pain, chronic fatigue, and fibromyalgia), bone fragility, and cancer. Dietary Mg and/or Mg consumed in drinking water (generally more bioavailable than Mg contained in food) or in alternative Mg supplements should be taken into consideration in the correction of Mg deficits. Maintaining an optimal Mg balance all through life may help in the prevention of oxidative stress and chronic conditions associated with aging. This needs to be demonstrated by future studies.

Indexed as

AgedAgingAnimalsHumansMagnesiumMagnesium DeficiencyMagnesiumagingdementiadiabetesdiseaseshealthhypertensionlongevitymagnesiumosteoporosisoxidative stress

Identifiers

PMID33573164
PMCPMC7912123
OpenAlexW3126793704

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.