Evidence map›Paper›PMID 33573261›Full record

ArticleMarine drugs2021

Bioactivity Screening and Gene-Trait Matching across Marine Sponge-Associated Bacteria.

Asimenia Gavriilidou, Thomas Andrew Mackenzie, Pilar Sánchez, José Ruben Tormo, Colin Ingham, Hauke Smidt, Detmer Sipkema

Abstract read
In one paragraph

Article in Marine drugs, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Asimenia GavriilidouLaboratory of Microbiology, Wageningen University and Research, 6708 WE Wageningen, The Netherlands.ORCID 0000-0003-0204-2223
Thomas Andrew MackenzieFundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Avda. del Conocimiento 34, 18016 Granada, Spain.
Pilar SánchezFundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Avda. del Conocimiento 34, 18016 Granada, Spain.
José Ruben TormoFundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Avda. del Conocimiento 34, 18016 Granada, Spain.ORCID 0000-0001-6984-2941
Colin InghamHoekmine BV, 3515 GJ Utrecht, The Netherlands.
Hauke SmidtLaboratory of Microbiology, Wageningen University and Research, 6708 WE Wageningen, The Netherlands.ORCID 0000-0002-6138-5026
Detmer SipkemaLaboratory of Microbiology, Wageningen University and Research, 6708 WE Wageningen, The Netherlands.ORCID 0000-0003-3836-219X

Funding

MarPipe 721421
6 · The paper itself

Abstract

Marine sponges harbor diverse microbial communities that represent a significant source of natural products. In the present study, extracts of 21 sponge-associated bacteria were screened for their antimicrobial and anticancer activity, and their genomes were mined for secondary metabolite biosynthetic gene clusters (BGCs). Phylogenetic analysis assigned the strains to four major phyla in the sponge microbiome, namely Proteobacteria, Actinobacteria, Bacteroidetes, and Firmicutes. Bioassays identified one extract with anti-methicillin-resistant

Indexed as

Drug Evaluation, PreclinicalMultigene FamilyAnimalsAnti-Infective AgentsAntineoplastic AgentsBacteriaGenome, BacterialPhylogenyPoriferaAnti-Infective AgentsAntineoplastic Agentsantibacterialanticancerbiosynthetic gene clustersgene-trait matchingsponge-associated bacteria

Identifiers

PMID33573261
PMCPMC7912018

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.