Evidence map›Paper›PMID 33573262›Full record

SynthesisNutrients2021

Effects of Maternal Nutritional Supplements and Dietary Interventions on Placental Complications: An Umbrella Review, Meta-Analysis and Evidence Map.

Mai-Lei Woo Kinshella, Shazmeen Omar, Kerri Scherbinsky, Marianne Vidler, Laura A Magee, Peter von Dadelszen, Sophie E Moore, Rajavel Elango, The Precise Conceptual Framework Working Group

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 6 pooled it
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 6 syntheses or guidelines pooled it, 45 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Fetal death: Expert consensus of the French College of Obstetricians and Gynecologists.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025
    Guideline
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Trial
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Dietary supplements and vascular function in hypertensive disorders of pregnancy.Pflugers Archiv : European journal of physiology · 2023
    Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 3 countries.

Mai-Lei Woo KinshellaDepartment of Obstetrics and Gynaecology, BC Children's and Women's Hospital and University of British Columbia, Vancouver, BC V6Z 2K8, Canada.ORCID 0000-0001-5846-3014
Shazmeen OmarDepartment of Obstetrics and Gynaecology, BC Children's and Women's Hospital and University of British Columbia, Vancouver, BC V6Z 2K8, Canada.
Kerri ScherbinskyDepartment of Obstetrics and Gynaecology, BC Children's and Women's Hospital and University of British Columbia, Vancouver, BC V6Z 2K8, Canada.
Marianne VidlerDepartment of Obstetrics and Gynaecology, BC Children's and Women's Hospital and University of British Columbia, Vancouver, BC V6Z 2K8, Canada.
Laura A MageeDepartment of Obstetrics and Gynaecology, BC Children's and Women's Hospital and University of British Columbia, Vancouver, BC V6Z 2K8, Canada.
Peter von DadelszenDepartment of Obstetrics and Gynaecology, BC Children's and Women's Hospital and University of British Columbia, Vancouver, BC V6Z 2K8, Canada.
Sophie E MooreDepartment of Women & Children's Health, King's College London, London WC2R 2LS, UK.
Rajavel ElangoDepartment of Pediatrics, University of British Columbia, Vancouver, BC V6H 0B3, Canada.ORCID 0000-0002-9380-1725
The Precise Conceptual Framework Working Group
University of British Columbia · CAKing's College London · GB

Funding

British Heart Foundation FS/15/32/31604CIHR FRN 10321Medical Research Council MC_PC_21037Medical Research Council MC_PC_MR/R019177/1Medical Research Council MC_U123292701Medical Research Council MC_UU_00026/3Medical Research Council MR/P012019/1Medical Research Council MR/P027938/1
6 · The paper itself

Abstract

The placenta is a vital, multi-functional organ that acts as an interface between maternal and fetal circulation during pregnancy. Nutritional deficiencies during pregnancy alter placental development and function, leading to adverse pregnancy outcomes, such as pre-eclampsia, infants with small for gestational age and low birthweight, preterm birth, stillbirths and maternal mortality. Maternal nutritional supplementation may help to mitigate the risks, but the evidence base is difficult to navigate. The primary purpose of this umbrella review is to map the evidence on the effects of maternal nutritional supplements and dietary interventions on pregnancy outcomes related to placental disorders and maternal mortality. A systematic search was performed on seven electronic databases, the PROSPERO register and references lists of identified papers. The results were screened in a three-stage process based on title, abstract and full-text by two independent reviewers. Randomized controlled trial meta-analyses on the efficacy of maternal nutritional supplements or dietary interventions were included. There were 91 meta-analyses included, covering 23 types of supplements and three types of dietary interventions. We found evidence that supports supplementary vitamin D and/or calcium, omega-3, multiple micronutrients, lipid-based nutrients, and balanced protein energy in reducing the risks of adverse maternal and fetal health outcomes. However, these findings are limited by poor quality of evidence. Nutrient combinations show promise and support a paradigm shift to maternal dietary balance, rather than single micronutrient deficiencies, to improve maternal and fetal health. The review is registered at PROSPERO (CRD42020160887).

Indexed as

Dietary SupplementsNutrition TherapyFemaleHumansMaternal Nutritional Physiological PhenomenaPlacenta DiseasesPregnancylow birthweightmaternal dietary interventionsmaternal mortalitynutritional supplementspre-eclampsiasmall for gestational agestillbirthsumbrella review

Identifiers

PMID33573262
PMCPMC7912620
OpenAlexW3126228244

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.