ArticleMetabolism: clinical and experimental1988
Quantification of the glycolytic origin of plasma glycerol: implications for the use of the rate of appearance of plasma glycerol as an index of lipolysis in vivo.
Article in Metabolism: clinical and experimental, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02833415 (Visceral Adiposity and Diabetes), which is not on this map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Visceral Adiposity and Diabetes: Translating Form to Function Using Imaging
Open the trial in the graphWho cites it
10 citing papers in PubMed, 54 citations in OpenAlex.
- Uptake and release of glucose by the human kidney. Postabsorptive rates and responses to epinephrine.The Journal of clinical investigation · 1995Trial
- Insulin receptorNature communications · 2026Article
- Glycerol and Glycerol-3-Phosphate: Multifaceted Metabolites in Metabolism, Cancer, and Other Diseases.Endocrine reviews · 2026Review
- Tracking the carbons supplying gluconeogenesis.The Journal of biological chemistry · 2020Review
- Glycerol is synthesized and secreted by adipocytes to dispose of excess glucose, via glycerogenesis and increased acyl-glycerol turnover.Scientific reports · 2017Article
- Methods for quantifying adipose tissue insulin resistance in overweight/obese humans.International journal of obesity (2005) · 2017Article
- Glycerol Production from Glucose and Fructose by 3T3-L1 Cells: A Mechanism of Adipocyte Defense from Excess Substrate.PloS one · 2015Article
- Metabolic signatures of exercise in human plasma.Science translational medicine · 2010Article
- Increased lipolysis and its consequences on gluconeogenesis in non-insulin-dependent diabetes mellitus.The Journal of clinical investigation · 1992Article
- Is muscle the major site of insulin resistance in type 2 (non-insulin-dependent) diabetes mellitus?Diabetologia · 1991Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
To assess whether plasma glycerol could be directly derived from plasma glucose, nine postabsorptive dogs were infused with [U-14C] glucose and [2-3H] glycerol to measure the rates of appearance of plasma glucose and glycerol and the conversion of plasma glucose to glycerol before (basal) and after two hours of infusion of glucose (45 mumol/kg/min). Basally (plasma glucose 4.9 +/- 0.2 mmol/L; plasma insulin 5.9 +/- 0.2 microU/mL), rates of appearance of plasma glucose and glycerol were 20 +/- 2 and 5.9 +/- 1.3 mumol/kg/min, respectively, and 1.6 +/- 0.6% of plasma glycerol was derived from plasma glucose. After glucose infusion (plasma glucose 9.1 +/- 0.7 mmol/L; plasma insulin 21.1 +/- 1.9 microU/mL), the rate of appearance of plasma glycerol decreased 80% to 1.1 +/- 0.3 mumol/kg/min and the percent of plasma glycerol from glucose increased significantly to 6.9 +/- 2.9. However, the absolute rate of conversion of glucose to glycerol did not change (0.09 +/- 0.03 v 0.07 +/- 0.03 mumol/kg/min). We conclude that even under conditions of stimulated glycolysis and inhibited lipolysis, only a small amount of plasma glycerol is derived from plasma glucose. Thus, rates of appearance of plasma glycerol can be used as a measure of rates of overall lipolysis in vivo.
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