ArticleNature communications2021
GWAS for autoimmune Addison's disease identifies multiple risk loci and highlights AIRE in disease susceptibility.
Open access · goldAbstract read
In one paragraph
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 3 pooled it
10.3field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 3 syntheses or guidelines pooled it, 82 citations in OpenAlex.
- Genome-wide meta-analysis of myasthenia gravis uncovers new loci and provides insights into polygenic prediction.Nature communications · 2024Pooled it
- Leveraging pleiotropy identifies common-variant associations with selective IgA deficiency.Clinical immunology (Orlando, Fla.) · 2024Pooled it
- Pooled it
- Tissue-specific clustering of genetic correlations across autoimmune diseases in a nationwide sibling study.The Journal of clinical investigation · 2026Article
- Systematic and proactive evaluation of AIRE missense variant effects.American journal of human genetics · 2026Article
- Immune markers mediate genetic relationships between immune diseases and psychiatric disorders.PLoS genetics · 2026Article
- Article
- Systematic and proactive evaluation of AIRE missense variant effects.bioRxiv : the preprint server for biology · 2025Article
- Causal associations between 17 common autoimmune diseases and aortic diseases: a Mendelian randomization study.International journal of cardiology. Cardiovascular risk and prevention · 2025Article
- Examining the genetic links between clusters of immune-mediated diseases and psychiatric disorders.Translational psychiatry · 2025Article
- Prevalence of Various Systemic and Organ-Specific Autoimmune Markers in Addison's Disease Patients Compared to Healthy Controls.Journal of clinical medicine · 2025Article
- Roles of TULA-family proteins in T cells and autoimmune diseases.Genes and immunity · 2025Review
- Aire Mutations and Autoimmune Diseases.Advances in experimental medicine and biology · 2025Review
- EndoCompass Project: Research Roadmap for Adrenal and Cardiovascular Endocrinology.Hormone research in paediatrics · 2025Review
- High-resolution transcriptional impact of AIRE: effects of pathogenic variants p.Arg257Ter, p.Cys311Tyr, and polygenic risk variant p.Arg471Cys.Frontiers in immunology · 2025Article
- The Putative Role ofInternational journal of molecular sciences · 2024Article
- Aire in Autoimmunity.Annual review of immunology · 2024Review
- Assessment of bidirectional relationships between autoimmune diseases and primary ovarian insufficiency: insights from a bidirectional two-sample Mendelian randomization analysis.Archives of gynecology and obstetrics · 2024Article
- Review
- Human-like adrenal features in Chinese tree shrews revealed by multi-omics analysis of adrenal cell populations and steroid synthesis.Zoological research · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
32 authors at 20 institutions in 3 countries.
Daniel Eriksson *Centre for Molecular Medicine, Department of Medicine (Solna), Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-5473-3312
Ellen Christine Røyrvik *Department of Clinical Science, University of Bergen, Bergen, Norway.ORCID 0000-0002-8979-1704
Maribel Aranda-Guillén *Centre for Molecular Medicine, Department of Medicine (Solna), Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0003-0050-704X
Amund Holte BergerDepartment of Clinical Science, University of Bergen, Bergen, Norway.ORCID 0000-0001-6973-2048
Nils LandegrenCentre for Molecular Medicine, Department of Medicine (Solna), Karolinska Institutet, Stockholm, Sweden.
Haydee ArtazaDepartment of Clinical Science, University of Bergen, Bergen, Norway.ORCID 0000-0002-1585-5488
Åsa HallgrenCentre for Molecular Medicine, Department of Medicine (Solna), Karolinska Institutet, Stockholm, Sweden.
Marianne Aardal GrytaasDepartment of Clinical Science, University of Bergen, Bergen, Norway.ORCID 0000-0001-9016-628X
Sara StrömDepartment of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital, Stockholm, Sweden.
Eirik BratlandDepartment of Clinical Science, University of Bergen, Bergen, Norway.
Ileana Ruxandra BotusanDepartment of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital, Stockholm, Sweden.
Bergithe Eikeland OftedalDepartment of Clinical Science, University of Bergen, Bergen, Norway.
Lars BreivikDepartment of Clinical Science, University of Bergen, Bergen, Norway.ORCID 0000-0003-2889-7342
Marc VaudelCenter for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway.ORCID 0000-0003-1179-9578
Øyvind HelgelandCenter for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway.ORCID 0000-0002-5612-2985
Alberto FalorniDepartment of Medicine, University of Perugia, Perugia, Italy.
Anders Palmstrøm JørgensenSection of Specialized Endocrinology, Department of Endocrinology, Oslo University Hospital, Oslo, Norway.ORCID 0000-0002-1246-9194
Anna-Lena HultingDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Johan SvartbergTromsø Endocrine Research Group, Department of Clinical Medicine, UiT The Arctic University of Norway, Tromsø, Norway.
Olov EkwallDepartment of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID 0000-0002-4506-9955
Kristian Johan FougnerDepartment of Endocrinology, St. Olavs Hospital, Trondheim, Norway.
Jeanette WahlbergDepartment of Endocrinology, Linköping University, Linköping, Sweden.
Bjørn Gunnar NedrebøDepartment of Clinical Science, University of Bergen, Bergen, Norway.
Per DahlqvistDepartment of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.ORCID 0000-0002-6471-9503
Norwegian Addison Registry Study Group
Swedish Addison Registry Study Group
Per Morten KnappskogDepartment of Clinical Science, University of Bergen, Bergen, Norway.
Anette Susanne Bøe WolffDepartment of Clinical Science, University of Bergen, Bergen, Norway.
Sophie BensingDepartment of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital, Stockholm, Sweden.ORCID 0000-0002-9193-2860
Stefan JohanssonDepartment of Clinical Science, University of Bergen, Bergen, Norway.ORCID 0000-0002-2298-7008
Olle KämpeCentre for Molecular Medicine, Department of Medicine (Solna), Karolinska Institutet, Stockholm, Sweden. olle.kampe@ki.se.ORCID 0000-0001-6091-9914
Eystein Sverre HusebyeCentre for Molecular Medicine, Department of Medicine (Solna), Karolinska Institutet, Stockholm, Sweden. eystein.sverre.husebye@helse-bergen.no.ORCID 0000-0002-7886-2976
Karolinska Institutet · SEHaukeland University Hospital · NOKarolinska University Hospital · SEUniversity of Bergen · NOVestre Viken Hospital Trust · NOLinköping University · SEUniversity of Gothenburg · SEInnlandet Hospital Trust · NOAkershus University Hospital · NOHaraldsplass Diakonale Sykehus · NOLund University · SEOslo University Hospital · NOØstfold Hospital Trust · NOUmeå University · SEUppsala University · SEÅlesund Hospital · NODiakonhjemmet Hospital · NOHelse Førde · NOKristiansund Sykehus · NOLevanger Hospital · NO
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autoimmune Addison's disease (AAD) is characterized by the autoimmune destruction of the adrenal cortex. Low prevalence and complex inheritance have long hindered successful genetic studies. We here report the first genome-wide association study on AAD, which identifies nine independent risk loci (P < 5 × 10
Indexed as
Genome-Wide Association StudyAddison DiseaseBasic-Leucine Zipper Transcription FactorsCTLA-4 AntigenFemaleHumansMaleModels, MolecularProtein Tyrosine Phosphatase, Non-Receptor Type 22RiskBACH2 protein, humanBasic-Leucine Zipper Transcription FactorsCTLA-4 AntigenCTLA4 protein, humanProtein Tyrosine Phosphatase, Non-Receptor Type 22PTPN22 protein, human
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.