Evidence map›Paper›PMID 33576446›Full record

ArticleMolecular medicine reports2021

Comparison and optimisation of microRNA extraction from the plasma of healthy pregnant women.

Victoria L Parker, Bryony F Cushen, Eleftherios Gavriil, Benjamin Marshall, Sarah Waite, Allan Pacey, Paul R Heath

Open access · hybridAbstract readComparative Study
In one paragraph

Article in Molecular medicine reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Victoria L ParkerDepartment of Oncology and Metabolism, The University of Sheffield, Sheffield S10 2SF, UK.
Bryony F CushenDepartment of Oncology and Metabolism, The University of Sheffield, Sheffield S10 2SF, UK.
Eleftherios GavriilDepartment of Oncology and Metabolism, The University of Sheffield, Sheffield S10 2SF, UK.
Benjamin MarshallDepartment of Oncology and Metabolism, The University of Sheffield, Sheffield S10 2SF, UK.
Sarah WaiteDepartment of Oncology and Metabolism, The University of Sheffield, Sheffield S10 2SF, UK.
Allan PaceyDepartment of Oncology and Metabolism, The University of Sheffield, Sheffield S10 2SF, UK.
Paul R HeathSheffield Institute of Translational Neuroscience, The University of Sheffield, Sheffield S10 2HQ, UK.
University of Sheffield · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circulating microRNA (miRNA) biomarkers are implicated in the diagnosis, monitoring and prediction of various disease processes. Before embarking upon biomarker discovery, miRNA extraction techniques must first be optimised in the biofluid and population under study. Using plasma from a healthy pregnant woman, it was attempted to optimise and compare the performance of two commercially available miRNA extraction kits; Qiagen (miRNeasy Serum/Plasma) and Promega (Maxwell

Indexed as

BiomarkersCirculating MicroRNAFemaleHumansMicroRNAsPregnancyReagent Kits, DiagnosticReproducibility of ResultsReverse Transcriptase Polymerase Chain ReactionBiomarkersCirculating MicroRNAMicroRNAsReagent Kits, DiagnosticextractionHomo sapiensmicrornaoptimisationpregnancywomen

Identifiers

PMID33576446
PMCPMC7893782
OpenAlexW3127138723

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.