Evidence map›Paper›PMID 33577349›Full record

ArticleAnnual review of clinical psychology2021

Clinical and Translational Implications of an Emerging Developmental Substructure for Autism.

John N Constantino, Tony Charman, Emily J H Jones

Open access · bronzeAbstract read
In one paragraph

Article in Annual review of clinical psychology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 49 citations in OpenAlex.

  1. Challenging the Developmental Substructure Model for Autism: A Perspective From Causal Statistics.Autism research : official journal of the International Society for Autism Research · 2026
    Article
  2. Review
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  6. Decoding the genetic landscape of autism: A comprehensive review.World journal of clinical pediatrics · 2024
    Article
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  17. Unique dynamic profiles of social attention in autistic females.Journal of child psychology and psychiatry, and allied disciplines · 2022
    Article
  18. Article
  19. Article
  20. Patterns of objectively measured motor activity among infants developing ASD and concerns for ADHD.Journal of child psychology and psychiatry, and allied disciplines · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

John N ConstantinoDepartment of Psychiatry, Washington University School of Medicine, St. Louis, Missouri 63110, USA; email: constantino@wustl.edu.
Tony CharmanDepartment of Psychology, King's College London Institute of Psychiatry, Psychology & Neuroscience, London SE5 8AF, United Kingdom.
Emily J H JonesCentre for Brain & Cognitive Development, Birkbeck, University of London, London WC1E 7HX, United Kingdom.
Birkbeck, University of London · GBKing's College London · GBWashington University in St. Louis · US

Funding

WUIDDRC Supplement-Supporting the health and well-being of children with intellectual and developmental disability during COVID-19 pandemicP50HD103525 · NICHD · WASHINGTON UNIVERSITY · PI JEFFREY D MILBRANDT · 2020 to 2026
$15.5M
Medical Research Council MR/K021389/1Medical Research Council MR/R011427/1Medical Research Council MR/T003057/1NICHD NIH HHS P50 HD103525
6 · The paper itself

Abstract

A vast share of the population-attributable risk for autism relates to inherited polygenic risk. A growing number of studies in the past five years have indicated that inherited susceptibility may operate through a finite number of early developmental liabilities that, in various permutations and combinations, jointly predict familial recurrence of the convergent syndrome of social communication disability that defines the condition. Here, we synthesize this body of research to derive evidence for a novel developmental substructure for autism, which has profound implications for ongoing discovery efforts to elucidate its neurobiological causes, and to inform future clinical and biomarker studies, early interventions, and personalized approaches to therapy.

Indexed as

Autism Spectrum DisorderAutistic DisorderHumanscanalizationcausationdevelopmentendophenotypeinfancyinheritance

Identifiers

PMID33577349
PMCPMC9014692
OpenAlexW3129117087

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.