Evidence map›Paper›PMID 33579965›Full record

ArticleNature communications2021

Multiple mechanisms drive genomic adaptation to extreme O

Arya Iranmehr, Tsering Stobdan, Dan Zhou, Huiwen Zhao, Sergey Kryazhimskiy, Vineet Bafna, Gabriel G Haddad

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. The Pupa Stage Is the Most Sensitive to Hypoxia inInternational journal of molecular sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Arya Iranmehr *Department of Electrical & Computer Engineering, University of California, San Diego, La Jolla, CA, USA.
Tsering Stobdan *Division of Respiratory Medicine, Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-2418-5156
Dan Zhou *Division of Respiratory Medicine, Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA. d2zhou@health.ucsd.edu.ORCID 0000-0001-6401-9040
Huiwen ZhaoDivision of Respiratory Medicine, Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA.
Sergey KryazhimskiyDivision of Biological Sciences, University of California, San Diego, La Jolla, CA, USA.
Vineet BafnaDepartment of Computer Science & Engineering, University of California, San Diego, La Jolla, CA, USA. vbafna@ucsd.edu.ORCID 0000-0002-5810-6241
Gabriel G HaddadDivision of Respiratory Medicine, Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA. ghaddad@health.ucsd.edu.
University of California San Diego · USUC San Diego Health System · US

Funding

Computational methods for detecting patterns of complex genomic variationR01GM114362 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Vineet Bafna · 2016 to 2026
$3.1M
Molecular Basis of Hypoxia-Induced Excessive ErythrocytosisR01HL146530 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HADDAD, GABRIEL G · 2019 to 2022
$2.4M
Genetic Mechanisms Regulating Hypoxia Tolerance in the BrainR21NS111270 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HADDAD, GABRIEL G · 2020 to 2020
$434k
NHLBI NIH HHS R01 HL146530NIGMS NIH HHS R01 GM114362NINDS NIH HHS R21 NS111270
6 · The paper itself

Abstract

To detect the genomic mechanisms underlying evolutionary dynamics of adaptation in sexually reproducing organisms, we analyze multigenerational whole genome sequences of Drosophila melanogaster adapting to extreme O

Indexed as

Genome, InsectGenomicsAdaptation, PhysiologicalAllelesAnimalsDrosophila melanogasterEvolution, MolecularFemaleGene FrequencyHaplotypesMaleOxygenWhole Genome SequencingOxygen

Identifiers

PMID33579965
PMCPMC7881140
OpenAlexW3126501650

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.