Evidence map›Paper›PMID 33580745›Full record

Trial reportClinical pharmacology in drug development2021

Safety of a Novel Weight Loss Combination Product Containing Orlistat and Acarbose.

Stefan Grudén, Anders Forslund, Göran Alderborn, Arvid Söderhäll, Per M Hellström, Ulf Holmbäck

Open access · hybridAbstract readClinical Trial, Phase IIRandomized Controlled Trial
In one paragraph

Trial report in Clinical pharmacology in drug development, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Heliyon · 2022
    Article
  5. Reversal and Remission of T2DM - An Update for Practitioners.Vascular health and risk management · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Stefan GrudénEmpros Pharma AB, Solna, Sweden.
Anders ForslundEmpros Pharma AB, Solna, Sweden.
Göran AlderbornEmpros Pharma AB, Solna, Sweden.
Arvid SöderhällEmpros Pharma AB, Solna, Sweden.
Per M HellströmDepartment of Medical Sciences, Uppsala University, Uppsala, Sweden.
Ulf HolmbäckEmpros Pharma AB, Solna, Sweden.
Empros Pharma (Sweden) · SEUppsala University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The safety of a novel modified-release oral capsule with orlistat and acarbose (MR-OA) was investigated in 67 obese middle-aged White men with a body mass index of 32 to 40 kg/m

Indexed as

AcarboseAdministration, OralAdultAnti-Obesity AgentsDrug CombinationsFollow-Up StudiesGlycoside Hydrolase InhibitorsHumansMaleMiddle AgedObesityOrlistatWeight LossAcarboseAnti-Obesity AgentsDrug CombinationsGlycoside Hydrolase InhibitorsOrlistatfixed-dose combinationgastrointestinal tolerabilitymodified releaseobesity treatmentweight loss product

Identifiers

PMID33580745
PMCPMC8518499
OpenAlexW3126755783

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.