Evidence map›Paper›PMID 33584607›Full record

ArticleFrontiers in microbiology2021

PF-429242, a Subtilisin Inhibitor, Is Effective

Patrícia de Almeida Machado, Pollyanna Stephanie Gomes, Victor Midlej, Elaine Soares Coimbra, Herbert Leonel de Matos Guedes

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 29 citations in OpenAlex.

  1. Exploring theAntimicrobial agents and chemotherapy · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Anti-Tropical medicine and infectious disease · 2023
    Article
  7. Meroterpenoids fromPharmaceuticals (Basel, Switzerland) · 2023
    Article
  8. Article
  9. Article
  10. The Natural Alkaloid Tryptanthrin Induces Apoptosis-like Death inTropical medicine and infectious disease · 2022
    Article
  11. Subtilisin ofCurrent issues in molecular biology · 2022
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Patrícia de Almeida MachadoLaboratório Interdisciplinar de Pesquisas Médicas, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, Brazil.
Pollyanna Stephanie GomesLaboratório Interdisciplinar de Pesquisas Médicas, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, Brazil.
Victor MidlejLaboratório de Ultraestrutura Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, Brazil.
Elaine Soares CoimbraNúcleo de Pesquisa em Parasitologia (NUPEP), Instituto de Ciências Biológicas, Universidade Federal de Juiz de Fora, Juiz de Fora, Brazil.
Herbert Leonel de Matos GuedesLaboratório Interdisciplinar de Pesquisas Médicas, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, Brazil.
Fundação Oswaldo Cruz · BRUniversidade Federal de Juiz de Fora · BRUniversidade Federal do Rio de Janeiro · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PF-429242 is an inhibitor of subtilisin, an important protease found in

Indexed as

leishmaniasis chemotherapyPF-429242serine proteasesubtilisinvisceral leishmaniasis

Identifiers

PMID33584607
PMCPMC7876069
OpenAlexW3126995578

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.