Evidence map›Paper›PMID 33587913›Full record

ReviewDevelopmental biology2021

Expanding the boundaries of synthetic development.

Iain Martyn, Zev J Gartner

Abstract readReview
In one paragraph

Review in Developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. The Mechanics of Building Functional Organs.Cold Spring Harbor perspectives in biology · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Unifying synthetic embryology.Developmental biology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Iain MartynDepartment of Pharmaceutical Chemistry, NSF Center for Cellular Construction, San Francisco, CA, USA.
Zev J GartnerDepartment of Pharmaceutical Chemistry, Chan Zuckerberg Biohub, NSF Center for Cellular Construction, San Francisco, CA, USA. Electronic address: zev.gartner@ucsf.edu.

Funding

The physical and molecular mechanisms of intestinal villus morphogenesis and repairR01DK126376 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Zev Jordan Gartner · 2020 to 2026
$4.2M
Understanding breast cancer progression as a defect in the mechanics of tissue self-organizationU01CA244109 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GARTNER, ZEV JORDAN, GOGA, ANDREI · 2020 to 2024
$3.0M
Total synthesis of the human mammary glandDP2HD080351 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GARTNER, ZEV JORDAN · 2013 to 2013
$2.4M
CIHRNCI NIH HHS U01 CA244109NICHD NIH HHS DP2 HD080351NIDDK NIH HHS R01 DK126376
6 · The paper itself

Abstract

Embryonic tissue boundaries are critical to not only cement newly patterned structures during development, but also to serve as organizing centers for subsequent rounds of morphogenesis. ​Although this latter role is especially difficult to study in vivo, synthetic embryology offers a new vantage point and fresh opportunities. In this review, we cover recent progress towards understanding and controlling in vitro boundaries and how they impact synthetic model systems. A key point this survey highlights is that the outcome of self-organization is strongly dependent on the boundary imposed, and new insight into the complex functions of embryonic boundaries will be necessary to create better self-organizing tissues for basic science, drug development, and regenerative medicine.

Indexed as

EmbryologySynthetic BiologyAnimalsEmbryo, MammalianExtracellular MatrixGenetic EngineeringHumansBioengineeringBoundariesSelf-organizationSynthetic embryology

Identifiers

PMID33587913
PMCPMC8052276

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.