ArticleNature immunology2021
A CD22-Shp1 phosphatase axis controls integrin β
Open access · bronzeAbstract readVideo-Audio Media
In one paragraph
Article in Nature immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
- Molecular Characterization and Expression Analysis ofBiology · 2026Article
- Elucidation of the Roles of CD22 Cis-Ligands in B Lymphocyte Development and Signaling Using Genetic and Chemical Tools.Advances in experimental medicine and biology · 2026Review
- Genetically Engineered Hypoimmune Human Muscle Progenitor Cells Can Reduce Immune Rejection.Cell proliferation · 2025Article
- N-Glycan Branching Regulates BTLA Opposite to PD-1 to Limit T Cell Hyperactivity Induced by Branching Deficiency.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- Role of Siglecs in viral infections: A double-edged sword interaction.Molecular aspects of medicine · 2023Review
- The Interplay between Integrins and Immune Cells as a Regulator in Cancer Immunology.International journal of molecular sciences · 2023Review
- Emerging phagocytosis checkpoints in cancer immunotherapy.Signal transduction and targeted therapy · 2023Review
- Expression of CD22 in Triple-Negative Breast Cancer: A Novel Prognostic Biomarker and Potential Target for CAR Therapy.International journal of molecular sciences · 2023Article
- The Notch1/CD22 signaling axis disrupts Treg function in SARS-CoV-2-associated multisystem inflammatory syndrome in children.The Journal of clinical investigation · 2023Article
- An NKX-COUP-TFII morphogenetic code directs mucosal endothelial addressin expression.Nature communications · 2022Article
- Comparative transcriptome analysis of rainbow trout gonadal cells (RTG-2) infected with U and J genogroup infectious hematopoietic necrosis virus.Frontiers in microbiology · 2022Article
- Development and function of tissue-resident memory B cells.Advances in immunology · 2022Article
- Siglec Signaling in the Tumor Microenvironment.Frontiers in immunology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 6 institutions in 4 countries.
Romain BalletPalo Alto Veterans Institute for Research, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA. ballet.r@gmail.com.ORCID http://orcid.org/0000-0002-5802-9346
Martin Brennan *Palo Alto Veterans Institute for Research, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA.
Carolin Brandl *Division of Genetics, Department of Biology, University of Erlangen, Erlangen, Germany.
Ningguo FengPalo Alto Veterans Institute for Research, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA.
Jeremy BerriPalo Alto Veterans Institute for Research, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA.
Julian ChengPalo Alto Veterans Institute for Research, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA.
Borja OcónPalo Alto Veterans Institute for Research, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA.
Amin Alborzian Deh SheikhDepartment of Immunology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.ORCID http://orcid.org/0000-0002-0284-9361
Alex MarkiLa Jolla Institute for Allergy and Immunology, La Jolla, CA, USA.
Yuhan BiPalo Alto Veterans Institute for Research, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA.
Clare L AbramDepartment of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.
Clifford A LowellDepartment of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.
Takeshi TsubataDepartment of Immunology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.ORCID http://orcid.org/0000-0003-0760-1258
Harry B GreenbergPalo Alto Veterans Institute for Research, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA.
Matthew S MacauleyDepartment of Chemistry, University of Alberta, Edmonton, Alberta, Canada.ORCID http://orcid.org/0000-0003-4579-1048
Klaus LeyLa Jolla Institute for Allergy and Immunology, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-9339-3672
Lars NitschkeDivision of Genetics, Department of Biology, University of Erlangen, Erlangen, Germany.
Eugene C ButcherPalo Alto Veterans Institute for Research, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA. ebutcher@stanford.edu.ORCID http://orcid.org/0000-0001-8786-7907
Palo Alto Veterans Institute for Research · USFriedrich-Alexander-Universität Erlangen-Nürnberg · DELa Jolla Institute for Immunology · USTokyo Medical and Dental University · JPUniversity of California, San Francisco · USUniversity of Alberta · CA
Funding
Vascular macrophages and T cells in atherosclerosisR35HL145241 · NHLBI · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI LEY, KLAUS F. · 2019 to 2025
$5.9MProgenitor Cells for High Endothelium in the Immune ResponseR01AI130471 · NIAID · PALO ALTO VETERANS INSTIT FOR RESEARCH · PI EUGENE C BUTCHER · 2017 to 2026
$5.0MIntestinal Lymphocyte TraffickingR37AI047822 · NIAID · PALO ALTO VETERANS INSTIT FOR RESEARCH · PI BUTCHER, EUGENE C · 2011 to 2020
$3.5MRegulation of Rotavirus Replication, Virulence, and Host Range Restriction by the Innate Immune SystemR01AI125249 · NIAID · PALO ALTO VETERANS INSTIT FOR RESEARCH · PI GREENBERG, HARRY BERNARD · 2017 to 2021
$2.1MRole of CD22 in the Germinal Center ReactionR01AI118842 · NIAID · UNIVERSITY OF ALBERTA · PI MACAULEY, MATTHEW SCOTT · 2017 to 2021
$1.4MRotavirus: Studies of the Effectors and Mechanisms of Heterotypic Humoral Immunity in Human Intestinal Epithelial CellsI01BX000158 · VA · VETERANS ADMIN PALO ALTO HEALTH CARE SYS · PI GREENBERG, HARRY BERNARD · 2011 to 2022
–BLRD VA I01 BX000158BLRD VA I01 BX002919NHLBI NIH HHS R35 HL145241NIAID NIH HHS R01 AI118842NIAID NIH HHS R01 AI125249NIAID NIH HHS R01 AI130471NIAID NIH HHS R37 AI047822Swiss National Science Foundation 162055Swiss National Science Foundation 174365
Abstract
The integrin α
Indexed as
Immunity, MucosalAnimalsB-LymphocytesChemotaxis, LeukocyteDisease Models, AnimalEndocytosisFemaleIntegrin beta ChainsIntegrinsIntestinal MucosaMaleMiceMice, Inbred BALB CMice, Inbred C57BLMice, KnockoutPhosphorylationCd22 protein, mouseintegrin alpha4beta7integrin beta7Integrin beta ChainsIntegrinsProtein Tyrosine Phosphatase, Non-Receptor Type 6Ptpn6 protein, mouseSialic Acid Binding Ig-like Lectin 2
Identifiers
What Socratic holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.