ArticleRadiology2021
Contribution of Risk Factors to the Development of Coronary Atherosclerosis as Confirmed via Coronary CT Angiography: A Longitudinal Radiomics-based Study.
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Article in Radiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19citing papers in PubMed
5.2field-weighted citation impact, top 3% of its field
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Who cites it
19 citing papers in PubMed, 42 citations in OpenAlex.
- Coronary Plaque Radiomic Phenotypes Predict Fatal or Nonfatal Myocardial Infarction: Analysis of the SCOT-HEART Trial.JACC. Cardiovascular imaging · 2025Trial
- Cancer classification with radiomics in controlled preclinical models.Scientific reports · 2026Article
- Multimodal prediction of major adverse cardiovascular events in hypertensive patients with coronary artery disease: integrating pericoronary fat radiomics, CT-FFR, and clinicoradiological features.La Radiologia medica · 2025Article
- Immune Dysregulation in Ischemic Heart Disease Among Individuals with Human Immunodeficiency Virus.Heart failure clinics · 2025Review
- Impact of technical, patient-related and measurement variables on serial Hounsfield unit-based quantitative coronary plaque analysis in computed tomography: time for a new chapter.European heart journal. Imaging methods and practice · 2025Review
- Pericoronary adipose tissue feature analysis in computed tomography calcium score images in comparison to coronary computed tomography angiography.Journal of medical imaging (Bellingham, Wash.) · 2025Article
- Plaque Characteristics Derived from Intravascular Optical Coherence Tomography That Predict Cardiovascular Death.Bioengineering (Basel, Switzerland) · 2024Article
- Protocol and rationale of the Australian multicentre registry for serial cardiac computed tomography angiography (ARISTOCRAT): a prospective observational study of the natural history of pericoronary adipose tissue attenuation and radiomics.Cardiovascular diagnosis and therapy · 2024Article
- Impact of virtual monoenergetic levels on coronary plaque volume components using photon-counting computed tomography.European radiology · 2023Article
- Imaging Early Life Cardiovascular Phenotype.Circulation research · 2023Review
- Radiomics features of pericoronary adipose tissue improve CT-FFR performance in predicting hemodynamically significant coronary artery stenosis.European radiology · 2023Article
- Classification of high-risk coronary plaques using radiomic analysis of multi-energy photon-counting-detector computed tomography (PCD-CT) images.Proceedings of SPIE--the International Society for Optical Engineering · 2023Article
- Artificial intelligence in coronary computed tomography angiography: Demands and solutions from a clinical perspective.Frontiers in cardiovascular medicine · 2023Review
- Temporal assessment of lesion morphology on radiological images beyond lesion volumes-a proof-of-principle study.European radiology · 2022Article
- CAD-RADS may underestimate coronary plaque progression as detected by serial CT angiography.European heart journal. Cardiovascular Imaging · 2022Article
- Radiomics-Based Precision Phenotyping Identifies Unstable Coronary Plaques From Computed Tomography Angiography.JACC. Cardiovascular imaging · 2022Article
- Editorial: Radiomics in Cardiovascular Imaging.Frontiers in cardiovascular medicine · 2022Article
- Deep Learning With Radiomics for Disease Diagnosis and Treatment: Challenges and Potential.Frontiers in oncology · 2022Review
- Cardiac Computed Tomography Radiomics for the Non-Invasive Assessment of Coronary Inflammation.Cells · 2021Review
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Authors and funding
10 authors at 1 institution in 2 countries.
Márton KolossváryFrom the Departments of Pathology (M.K., T.S.K., S.C., S.B., S.L.), Medicine (G.G., S.L.), and Radiology (E.K.F., S.L., H.L.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287; Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, Budapest, Hungary (M.K.); Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wis (D.A.B.); and National Institute on Drug Abuse, National Institutes of Health, Bethesda, Md (R.N.M.).ORCID 0000-0002-5570-991X
Gary GerstenblithFrom the Departments of Pathology (M.K., T.S.K., S.C., S.B., S.L.), Medicine (G.G., S.L.), and Radiology (E.K.F., S.L., H.L.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287; Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, Budapest, Hungary (M.K.); Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wis (D.A.B.); and National Institute on Drug Abuse, National Institutes of Health, Bethesda, Md (R.N.M.).
David A BluemkeFrom the Departments of Pathology (M.K., T.S.K., S.C., S.B., S.L.), Medicine (G.G., S.L.), and Radiology (E.K.F., S.L., H.L.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287; Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, Budapest, Hungary (M.K.); Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wis (D.A.B.); and National Institute on Drug Abuse, National Institutes of Health, Bethesda, Md (R.N.M.).ORCID 0000-0002-8323-8086
Elliot K FishmanFrom the Departments of Pathology (M.K., T.S.K., S.C., S.B., S.L.), Medicine (G.G., S.L.), and Radiology (E.K.F., S.L., H.L.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287; Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, Budapest, Hungary (M.K.); Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wis (D.A.B.); and National Institute on Drug Abuse, National Institutes of Health, Bethesda, Md (R.N.M.).ORCID 0000-0002-2567-1658
Raul N MandlerFrom the Departments of Pathology (M.K., T.S.K., S.C., S.B., S.L.), Medicine (G.G., S.L.), and Radiology (E.K.F., S.L., H.L.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287; Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, Budapest, Hungary (M.K.); Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wis (D.A.B.); and National Institute on Drug Abuse, National Institutes of Health, Bethesda, Md (R.N.M.).
Thomas S KicklerFrom the Departments of Pathology (M.K., T.S.K., S.C., S.B., S.L.), Medicine (G.G., S.L.), and Radiology (E.K.F., S.L., H.L.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287; Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, Budapest, Hungary (M.K.); Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wis (D.A.B.); and National Institute on Drug Abuse, National Institutes of Health, Bethesda, Md (R.N.M.).
Shaoguang ChenFrom the Departments of Pathology (M.K., T.S.K., S.C., S.B., S.L.), Medicine (G.G., S.L.), and Radiology (E.K.F., S.L., H.L.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287; Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, Budapest, Hungary (M.K.); Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wis (D.A.B.); and National Institute on Drug Abuse, National Institutes of Health, Bethesda, Md (R.N.M.).
Sandeepan BhatiaFrom the Departments of Pathology (M.K., T.S.K., S.C., S.B., S.L.), Medicine (G.G., S.L.), and Radiology (E.K.F., S.L., H.L.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287; Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, Budapest, Hungary (M.K.); Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wis (D.A.B.); and National Institute on Drug Abuse, National Institutes of Health, Bethesda, Md (R.N.M.).ORCID 0000-0002-6242-8833
Shenghan LaiFrom the Departments of Pathology (M.K., T.S.K., S.C., S.B., S.L.), Medicine (G.G., S.L.), and Radiology (E.K.F., S.L., H.L.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287; Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, Budapest, Hungary (M.K.); Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wis (D.A.B.); and National Institute on Drug Abuse, National Institutes of Health, Bethesda, Md (R.N.M.).ORCID 0000-0003-1340-9609
Hong LaiFrom the Departments of Pathology (M.K., T.S.K., S.C., S.B., S.L.), Medicine (G.G., S.L.), and Radiology (E.K.F., S.L., H.L.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287; Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, Budapest, Hungary (M.K.); Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wis (D.A.B.); and National Institute on Drug Abuse, National Institutes of Health, Bethesda, Md (R.N.M.).ORCID 0000-0003-2918-2381
Semmelweis University · HU
Funding
Effects of HIV, Cocaine, and Prolonged ART Use on Subclinical Cardiovascular DiseaseU01DA040325 · NIDA · UNIVERSITY OF MARYLAND BALTIMORE · PI LAI, SHENGHAN · 2016 to 2024
$12.7MSubclinical Atherosclerosis in HIV plus Black Cocaine UsersR01DA012777 · NIDA · JOHNS HOPKINS UNIVERSITY · PI LAI, SHENGHAN · 1999 to 2014
$8.2MHIV Infection, Cocaine Use and Coronary Artery Disease in HIV+ African AmericansR01DA025524 · NIDA · JOHNS HOPKINS UNIVERSITY · PI LAI, SHENGHAN · 2008 to 2012
$3.8MHIV, Cocaine &Regional Left Ventricular DysfunctionR01DA015020 · NIDA · JOHNS HOPKINS UNIVERSITY · PI LAI, SHENGHAN · 2002 to 2006
$3.4MThe Impact of Cocaine Abstinence or Reduced Use on Radiomic Features of Noncalcified Coronary Plaques in HIV-Infected Cocaine Users with Silent Coronary Artery DiseaseR21DA048780 · NIDA · UNIVERSITY OF MARYLAND BALTIMORE · PI LAI, SHENGHAN · 2019 to 2020
$436kNIDA NIH HHS R01 DA012777NIDA NIH HHS R01 DA015020NIDA NIH HHS R01 DA025524NIDA NIH HHS R21 DA048780NIDA NIH HHS U01 DA040325
Abstract
Background Various cardiovascular risk factors are thought to modify atherosclerosis in a similar fashion (ie, by increasing the magnitude of coronary artery disease [CAD]). However, coronary CT angiography allows precision phenotyping of plaque characteristics through use of radiomics. Purpose To assess whether different cardiovascular risk factors have distinctive contributions to the changes in plaque morphologic features over time. Materials and Methods Individuals with or without HIV infection and cocaine use and without cardiovascular symptoms underwent coronary CT angiography between May 2004 and August 2015. In the current HIPAA-compliant study, the effects of cocaine use, HIV infection, and atherosclerotic cardiovascular disease (ASCVD) risk on the temporal changes (mean ± standard deviation, 4.0 years ± 2.3 between CT angiographic examinations) in CAD structure were analyzed by using radiomic analysis. The changes in radiomic features were analyzed by using linear mixed models, with correction for factors that may change plaque structure: high-sensitivity C-reactive protein level, statin use, positive family history of CAD, and total plaque volume to account for any potential intrinsic correlation between volume and morphologic features. Clusters among significant radiomic features were identified by using hierarchical clustering. Bonferroni-corrected
Indexed as
Cocaine-Related DisordersComputed Tomography AngiographyCoronary AngiographyCoronary Artery DiseaseC-Reactive ProteinFemaleGenetic Predisposition to DiseaseHIV InfectionsHumansHydroxymethylglutaryl-CoA Reductase InhibitorsLongitudinal StudiesMaleMiddle AgedPhenotypePlaque, AtheroscleroticRisk FactorsC-Reactive ProteinHydroxymethylglutaryl-CoA Reductase Inhibitors
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.