ArticlePLoS biology2021
The protease corin regulates electrolyte homeostasis in eccrine sweat glands.
Article in PLoS biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Development and validation of an immune-related molecular subtyping model based on a four-gene prognostic biomarker signature and multi-omics integrative analysis in Luminal B breast cancer.Breast cancer research : BCR · 2026Article
- Positively charged cytoplasmic residues in corin prevent signal peptidase cleavage and endoplasmic reticulum retention.Communications biology · 2025Article
- Cardiac corin and atrial natriuretic peptide regulate liver glycogen metabolism and glucose homeostasis.Cardiovascular diabetology · 2024Article
- Deficiencies in corin and atrial natriuretic peptide-mediated signaling impair endochondral ossification in bone development.Communications biology · 2024Article
- Natriuretic Peptide Signaling in Uterine Biology and Preeclampsia.International journal of molecular sciences · 2023Review
- Article
- Type II Transmembrane Serine Proteases as Modulators in Adipose Tissue Phenotype and Function.Biomedicines · 2023Review
- Role of epithelial sodium channel-related inflammation in human diseases.Frontiers in immunology · 2023Review
- Corin deficiency impairs cardiac function in mouse models of heart failure.Frontiers in cardiovascular medicine · 2023Article
- Review
- Renal Corin Is Essential for Normal Blood Pressure and Sodium Homeostasis.International journal of molecular sciences · 2022Article
- [Research advances on the regulatory mechanism of sweat secretion ion channels of eccrine sweat glands].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2022Review
- Article
- Review
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14 authors.
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Abstract
Sweating is a basic skin function in body temperature control. In sweat glands, salt excretion and reabsorption are regulated to avoid electrolyte imbalance. To date, the mechanism underlying such regulation is not fully understood. Corin is a transmembrane protease that activates atrial natriuretic peptide (ANP), a cardiac hormone essential for normal blood volume and pressure. Here, we report an unexpected role of corin in sweat glands to promote sweat and salt excretion in regulating electrolyte homeostasis. In human and mouse eccrine sweat glands, corin and ANP are expressed in the luminal epithelial cells. In corin-deficient mice on normal- and high-salt diets, sweat and salt excretion is reduced. This phenotype is associated with enhanced epithelial sodium channel (ENaC) activity that mediates Na+ and water reabsorption. Treatment of amiloride, an ENaC inhibitor, normalizes sweat and salt excretion in corin-deficient mice. Moreover, treatment of aldosterone decreases sweat and salt excretion in wild-type (WT), but not corin-deficient, mice. These results reveal an important regulatory function of corin in eccrine sweat glands to promote sweat and salt excretion.
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