Evidence map›Paper›PMID 33592309›Full record

ReviewFree radical biology & medicine2021

Redox signaling as a modulator of germline stem cell behavior: Implications for regenerative medicine.

Rafael Sênos Demarco, D Leanne Jones

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Free radical biology & medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Oxidative Stress and Male Reproductive Health-First Edition.Antioxidants (Basel, Switzerland) · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Rafael Sênos DemarcoDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA, USA.
D Leanne JonesDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA, USA; Molecular Biology Institute, University of California, Los Angeles, CA, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, CA, USA. Electronic address: leannejones@ucla.edu.
University of California, Los Angeles · US

Funding

Lipid mediated regulation of stem cell behavior and tissue homeostasisR01GM135767 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JONES, DANA LEANNE · 2020 to 2023
$1.8M
Regulation of intestinal stem cell behavior by occluding junctionsR01DK105442 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JONES, DANA LEANNE · 2017 to 2020
$1.7M
NIDDK NIH HHS R01 DK105442NIGMS NIH HHS R01 GM135767
6 · The paper itself

Abstract

Germline stem cells (GSCs) are crucial for the generation of gametes and propagation of the species. Both intrinsic signaling pathways and environmental cues are employed in order to tightly control GSC behavior, including mitotic divisions, the choice between self-renewal or onset of differentiation, and survival. Recently, oxidation-reduction (redox) signaling has emerged as an important regulator of GSC and gamete behavior across species. In this review, we will highlight the primary mechanisms through which redox signaling acts to influence GSC behavior in different model organisms (Caenorhabditis elegans, Drosophila melanogaster and Mus musculus). In addition, we will summarize the latest research on the use of antioxidants to support mammalian spermatogenesis and discuss potential strategies for regenerative medicine in humans to enhance reproductive fitness.

Indexed as

Drosophila melanogasterDrosophila ProteinsAnimalsCell DifferentiationGerm CellsOxidation-ReductionRegenerative MedicineStem CellsDrosophila ProteinsGermline stem cellsReactive oxygen speciesRedoxROSSpermatogonial stem cells

Identifiers

PMID33592309
PMCPMC8021480
OpenAlexW3131010257

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.