ReviewExperimental biology and medicine (Maywood, N.J.)2021
Dysregulation of brain dopamine systems in major depressive disorder.
Review in Experimental biology and medicine (Maywood, N.J.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 87 citations in OpenAlex.
- The impact of cannabis use on erectile dysfunction and sex hormones: a Mendelian randomization analysis.International journal of impotence research · 2025Pooled it
- Adjunctive Pharmacotherapy for Major Depressive Disorder with Anxiety Symptoms: from Monoamines to Recent Clinical Evidence.CNS drugs · 2026Review
- Exploring the Causality Between Mood Swings and Neurological Diseases: A Mendelian Randomization Study.Brain and behavior · 2026Article
- Cognitive Improvement and Microbiota-Gut-Brain Axis Regulation byMicroorganisms · 2026Article
- Involvement of Serotonergic and Dopaminergic Systems inPharmaceuticals (Basel, Switzerland) · 2026Article
- Depression in Chinese adolescents: prevalence, symptoms, risk factors, affected brain, diagnosis, and interventions.Frontiers in psychology · 2026Review
- The mediating role of depressive symptoms in the relationship between obesity-related triglyceride-glucose index and cognitive status among middle-aged and elderly adults: a large cohort study.Frontiers in psychiatry · 2026Article
- A potential neuroimaging biomarker for depression in migraine patients: imbalance in excitation and inhibition in the medial superior frontal cortex.Journal of psychiatry & neuroscience : JPN · 2026Article
- What is the Impact of Dopamine D2 Receptor in the Brain-Gut Axis? A Narrative Review of the Mechanism Based on Gut Microbiota in Modulating Emotion and Behavior.Alpha psychiatry · 2025Review
- From gums to moods: Exploring the impact of the oral microbiota on depression.Brain, behavior, & immunity - health · 2025Review
- Uncovering the genetic underpinnings for different psychiatric disorder combinations.Psychological medicine · 2025Article
- Neuromelanin-Sensitive MRI Contrast and Chronic Depression in Young Women.JAMA network open · 2025Article
- The Therapeutic Potential of Stem Cells in Depression.International journal of molecular sciences · 2025Review
- Arginine Metabolism and Adenosine Receptor Signals in the Cerebellum Contribute to Nicotine Withdrawal-Induced Anxiety/Depression-Like Behaviours.Addiction biology · 2025Article
- When Your Body Tells You to Not Breastfeed-The Connivance of Oxytocin, Prolactin, and Dopamine.International journal of molecular sciences · 2025Review
- Neural energy coding patterns of dopaminergic neural microcircuit and its impairment in major depressive disorder: A computational study.PLoS computational biology · 2025Article
- Efficacy of Transcranial Direct Current Stimulation (tDCS) on Neuropsychiatric Symptoms in Substance Use Disorder (SUD)-A Review and Insights into Possible Mechanisms of Action.Journal of clinical medicine · 2025Review
- An Updated Review on the Complex Association of Cardiovascular Disease (CVD) and Depression.Current cardiology reviews · 2025Review
- Exploring the Relationship Between Heart, Brain, and Depression.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2025Review
- Investigation of the relationship between food preferences and depression symptoms among undergraduate medical students: a cross-sectional study.Frontiers in nutrition · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Major depressive disorder (MDD or depression) is a debilitating neuropsychiatric syndrome with genetic, epigenetic, and environmental contributions. Depression is one of the largest contributors to chronic disease burden; it affects more than one in six individuals in the United States. A wide array of cellular and molecular modifications distributed across a variety of neuronal processes and circuits underlie the pathophysiology of depression-no established mechanism can explain all aspects of the disease. MDD suffers from a vast treatment gap worldwide, and large numbers of individuals who require treatment do not receive adequate care. This mini-review focuses on dysregulation of brain dopamine (DA) systems in the pathophysiology of MDD and describing new cellular targets for potential medication development focused on DA-modulated micro-circuits. We also explore how neurodevelopmental factors may modify risk for later emergence of MDD, possibly through dopaminergic substrates in the brain.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.