Evidence map›Paper›PMID 33593603›Full record

ReviewTrends in biotechnology2021

Building Organs Using Tissue-Specific Microenvironments: Perspectives from a Bioprosthetic Ovary.

Nathaniel F C Henning, Adam E Jakus, Monica M Laronda

Abstract readReview
In one paragraph

Review in Trends in biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Discussing the final size and shape of the reconstructed tissues in tissue engineering.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2023
    Review
  11. Article
  12. A synopsis of global frontiers in fertility preservation.Journal of assisted reproduction and genetics · 2022
    Review
  13. Mechanobiology of the female reproductive system.Reproductive medicine and biology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Nathaniel F C HenningStanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, and Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Adam E JakusDimension Inx, Chicago, IL, USA.
Monica M LarondaStanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, and Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. Electronic address: mlaronda@luriechildrens.org.

Funding

Defining the microenvironment that will enable a long-term bioprosthetic ovary transplantR01HD104683 · NICHD · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI LARONDA, MONICA M · 2021 to 2025
$1.5M
NICHD NIH HHS R01 HD104683
6 · The paper itself

Abstract

Recent research in tissue engineering and regenerative medicine has elucidated the importance of the matrisome. The matrisome, effectively the skeleton of an organ, provides physical and biochemical cues that drive important processes such as differentiation, proliferation, migration, and cellular morphology. Leveraging the matrisome to control these and other tissue-specific processes will be key to developing transplantable bioprosthetics. In the ovary, the physical and biological properties of the matrisome have been implicated in controlling the important processes of follicle quiescence and folliculogenesis. This expanding body of knowledge is being applied in conjunction with new manufacturing processes to enable increasingly complex matrisome engineering, moving closer to emulating tissue structure, composition, and subsequent functions which can be applied to a variety of tissue engineering applications.

Indexed as

Cellular MicroenvironmentExtracellular MatrixOvaryProstheses and ImplantsTissue EngineeringFemaleHumansRegenerative Medicinebioengineeringmatrisomeovaryregenerative medicinetissue engineering

Identifiers

PMID33593603
PMCPMC8967215

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.