Evidence map›Paper›PMID 33594499›Full record

ArticlePflugers Archiv : European journal of physiology2021

Upregulation of transient receptor potential melastatin 4 (TRPM4) in ventricular fibroblasts from heart failure patients.

Jianlin Feng, Pengyu Zong, Jiajie Yan, Zhichao Yue, Xin Li, Chevaughn Smith, Xun Ai, Lixia Yue

Open access · greenAbstract read
In one paragraph

Article in Pflugers Archiv : European journal of physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Stress-Induced calcium mishandling in cardiac (Patho)physiology.Cellular and molecular life sciences : CMLS · 2025
    Review
  3. Article
  4. Review
  5. Article
  6. CaBiomedicines · 2025
    Review
  7. Article
  8. The Dysfunction of CaInternational journal of molecular sciences · 2023
    Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Calcium and Heart Failure: How Did We Get Here and Where Are We Going?International journal of molecular sciences · 2021
    Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jianlin FengCalhoun Cardiology Center, Department of Cell Biology, University of Connecticut School of Medicine (UConn Health), Farmington, CT, 06030, USA.
Pengyu ZongCalhoun Cardiology Center, Department of Cell Biology, University of Connecticut School of Medicine (UConn Health), Farmington, CT, 06030, USA.
Jiajie YanDepartment of Physiology and Biophysics, Rush University Medical Center, Chicago, IL, 60612, USA.
Zhichao YueCalhoun Cardiology Center, Department of Cell Biology, University of Connecticut School of Medicine (UConn Health), Farmington, CT, 06030, USA.
Xin LiCalhoun Cardiology Center, Department of Cell Biology, University of Connecticut School of Medicine (UConn Health), Farmington, CT, 06030, USA.
Chevaughn SmithCalhoun Cardiology Center, Department of Cell Biology, University of Connecticut School of Medicine (UConn Health), Farmington, CT, 06030, USA.
Xun AiDepartment of Physiology and Biophysics, Rush University Medical Center, Chicago, IL, 60612, USA.
Lixia YueCalhoun Cardiology Center, Department of Cell Biology, University of Connecticut School of Medicine (UConn Health), Farmington, CT, 06030, USA. lyue@uchc.edu.ORCID http://orcid.org/0000-0002-3558-091X
UConn Health · USRush University Medical Center · US

Funding

Sarcomeric Modifications and Progressive Cardiac MaladaptationP01HL062426 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI SOLARO, R JOHN · 2000 to 2020
$42.4M
Ca2+ signaling mechanisms in cardiac fibrosisR01HL078960 · NHLBI · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI YUE, LIXIA · 2005 to 2015
$3.9M
The Stress Response Kinase JNK and Alcohol Evoked Atrial FibrillationR01AA024769 · NIAAA · OHIO STATE UNIVERSITY · PI AI, XUN · 2017 to 2021
$3.3M
Heart-platelet crosstalk: JNK, AF, and thrombogenesisR01HL146744 · NHLBI · RUSH UNIVERSITY MEDICAL CENTER · PI Xun Ai, Yuchi Han · 2019 to 2026
$3.2M
Atrial and blood JNK in Postoperative AFR01HL168728 · NHLBI · OHIO STATE UNIVERSITY · PI Xun Ai · 2023 to 2026
$2.7M
Regulation of TRPM7 ChannelsR01HL147350 · NHLBI · RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL · PI RUNNELS, LOREN W, YUE, LIXIA · 2019 to 2022
$2.4M
American Heart Association-American Stroke Association 19TPA34890022NHLBI NIH HHS P01 HL062426NHLBI NIH HHS P01-HL06426NHLBI NIH HHS R01 HL078960NHLBI NIH HHS R01-HL143750NHLBI NIH HHS R01 HL146744NHLBI NIH HHS R01-HL146744NHLBI NIH HHS R01 HL147350NHLBI NIH HHS R01 HL168728NIAAA NIH HHS R01 AA024769NIH HHS R01-AA024769
6 · The paper itself

Abstract

The transient receptor potential melastatin 4 (TRPM4) is a Ca

Indexed as

FemaleFibroblastsHeart FailureHeart VentriclesHumansMaleMiddle AgedMyocytes, CardiacTRPM Cation ChannelsUp-RegulationTRPM4 protein, humanTRPM Cation ChannelsCalcium signalingHeart failureHuman ventricular fibroblastsTRP channelsTRPM4

Identifiers

PMID33594499
PMCPMC8857941
OpenAlexW3132373296

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.