Evidence map›Paper›PMID 33595666›Full record

ReviewThe Journal of clinical endocrinology and metabolism2021

Long-Term Weight Loss Strategies for Obesity.

Karim Kheniser, David R Saxon, Sangeeta R Kashyap

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Journal of clinical endocrinology and metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05870943 (Hybrid Argon Plasma Coagulation and Endoscopic Sleeve Gastroplasty Trial), which is not on this map. Cited by 77 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05870943 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Hybrid Argon Plasma Coagulation and Endoscopic Sleeve Gastroplasty Trial: A Single-Center Randomized Controlled Validation Trial in a Community Setting

TypeinterventionalSponsorTrue You Weight LossRan2023 to 2025Enrolled48ConditionsObesityArmsHybrid Argon Plasma Coagulation, Endoscopic Sleeve Gastroplasty
3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Cognitive Behavioral Interventions for Children and Adolescents With Overweight or Obesity: A Systematic Review and Component Network Meta-Analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026
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  7. Obesity in South and Southeast Asia-A new consensus on care and management.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2023
    Guideline
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  19. DoesFood science & nutrition · 2026
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17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Karim KheniserCenter for Neurological Restoration, Cleveland Clinic, Cleveland, OH, USA.ORCID 0000-0003-4549-1512
David R SaxonDivision of Endocrinology, Metabolism and Diabetes, University of Colorado School of Medicine and Rocky Mountain VA Medical Center, Anschutz Medical Campus, Aurora, CO, USA.
Sangeeta R KashyapDepartment of Endocrinology and Metabolism, Cleveland Clinic, Cleveland, OH USA.ORCID 0000-0002-8152-4046

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextObesity is a chronic disease that is difficult to manage without holistic therapy. The therapeutic armamentarium for obesity primarily consists of 4 forms of therapy: lifestyle modification (ie, diet and exercise), cognitive behavioral therapy, pharmacotherapy, and bariatric surgery. EVIDENCE ACQUISITION: Evidence was consolidated from randomized controlled trials, observational studies, and meta-analyses. EVIDENCE SYNTHESIS: After 2 years, lifestyle interventions can facilitate weight loss that equates to ~5%. Even though lifestyle interventions are plagued by weight regain, they can have substantial effects on type 2 diabetes and cardiovascular disease risk. Although 10-year percentage excess weight loss can surpass 50% after bariatric surgery, weight regain is likely. To mitigate weight regain, instituting a multifactorial maintenance program is imperative. Such a program can integrate diet, exercise, and pharmacotherapy. Moreover, behavioral therapy can complement a maintenance program well.

conclusionsObesity is best managed by a multidisciplinary clinical team that integrates diet, exercise, and pharmacotherapy. Bariatric surgery is needed to manage type 2 diabetes and obesity in select patients.

Indexed as

Anti-Obesity AgentsBariatric SurgeryBehavior TherapyDiet, ReducingHumansLife StyleMeta-Analysis as TopicObesityObesity ManagementObservational Studies as TopicRandomized Controlled Trials as TopicTimeTreatment OutcomeAnti-Obesity Agentsbariatric surgerydietexerciseobesitypharmacotherapy

Identifiers

PMID33595666
PMCPMC8427732

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.