Evidence map›Paper›PMID 33597589›Full record

ArticleScientific reports2021

Metabolomic differences between critically Ill women and men.

Sowmya Chary, Karin Amrein, Jessica A Lasky-Su, Harald Dobnig, Kenneth B Christopher

Abstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Trial
  2. Article
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sowmya CharyBiogen, Inc., 225 Binney St, Cambridge, MA, 02142, USA.
Karin AmreinDivision of Endocrinology and Diabetology, Medical University of Graz, Auenbruggerplatz 15, 8036, Graz, Austria.
Jessica A Lasky-SuChanning Division of Network Medicine, Brigham and Women's Hospital, 181 Longwood Avenue, Boston, USA.
Harald DobnigThyroid Endocrinology Osteoporosis Institute Dobnig, Jakob-Redtenbachergasse 10, 8010, Graz, Austria.
Kenneth B ChristopherChanning Division of Network Medicine, Brigham and Women's Hospital, 181 Longwood Avenue, Boston, USA. kbchristopher@bwh.harvard.edu.

Funding

Integrative Metabolomics of Asthma SeverityR01HL123915 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LASKY-SU, JESSICA A · 2014 to 2023
$7.0M
Mechanistic insights into asthma pathogenesis through the integration of asthma genes, risk exposures, and metabolomicsR01HL141826 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LASKY-SU, JESSICA A · 2018 to 2021
$3.4M
Pharmacokinetics and metabolomics of vitamin D supplementation in critical illnessR01GM115774 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI CHRISTOPHER, KENNETH BRUCE · 2016 to 2018
$940k
NHLBI NIH HHS R01 HL123915NHLBI NIH HHS R01 HL141826NIGMS NIH HHS R01 GM115774
6 · The paper itself

Abstract

Metabolism differs in women and men at homeostasis. Critically ill patients have profound dysregulation of homeostasis and metabolism. It is not clear if the metabolic response to critical illness differs in women compared to men. Such sex-specific differences in illness response would have consequences for personalized medicine. Our aim was to determine the sex-specific metabolomic response to early critical illness. We performed a post-hoc metabolomics study of the VITdAL-ICU trial where subjects received high dose vitamin D

Indexed as

AgedAged, 80 and overBasal MetabolismCholecalciferolCritical IllnessFemaleHumansMaleMetabolomeMetabolomicsMiddle AgedSex CharacteristicsSex FactorsVitamin D DeficiencyCholecalciferol

Identifiers

PMID33597589
PMCPMC7889607

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.