ArticleScientific reports2021
Metabolomic analysis of Trichophyton rubrum and Microsporum canis during keratin degradation.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Remarkable Phenotypic Virulence Factors ofInternational journal of molecular sciences · 2024Pooled it
- Non-coding RNAs in dermatophytosis: Key regulators of host-fungal interactions and pathogenesis-A review.Virulence · 2026Review
- Dermatophytosis: An Update on Global Epidemiology.Journal of fungi (Basel, Switzerland) · 2026Review
- Prevalence of dermatophytosis in cats and dogs in türkiye: dominance of Microsporum canis and first detection of Trichophyton rubrum.BMC veterinary research · 2025Article
- Unveiling the Role of StuA in Transcription Regulation in Trichophyton rubrum: From Global Regulation Dynamics to the pH-Responsive Program Control.Mycopathologia · 2025Article
- Dermatophytosis in context of Trichophyton rubrum: host defense mechanisms, virulence factors, and treatment innovations.Molecular biology reports · 2025Review
- Antifungal effect of soilIranian journal of microbiology · 2025Article
- Keratinous bioresources: their generation, microbial degradation, and value enhancement for biotechnological applications.World journal of microbiology & biotechnology · 2025Review
- Multidrug-resistant keratinolytic dermatophytes and non-dermatophytes causing onychomycosis in outpatients.Future microbiology · 2025Article
- Causal Relationships Between Plasma Metabolites and Risk of Dermatomyositis.Clinical, cosmetic and investigational dermatology · 2025Article
- The Transcription Factor StuA Regulates Oxidative Stress-Responsive Genes inInternational journal of molecular sciences · 2024Article
- Host-Pathogen Interaction and Resistance Mechanisms in Dermatophytes.Pathogens (Basel, Switzerland) · 2024Review
- Molecular Signaling and Metabolic Responses during the Interaction between Human Keratinocytes (HaCaT) and the DermatophyteJournal of fungi (Basel, Switzerland) · 2024Article
- Comparative genomic and phenotypic analyses of pathogenic fungi Neoscytalidium dimidiatum and Bipolaris papendorfii isolated from human skin scraping.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023Article
- Solvent influence on the crystal structures of new cadmium tri-tert-butoxysilanethiolate complexes with 1,4-bis(3-aminopropyl)piperazine: luminescence and antifungal activity.Acta crystallographica. Section C, Structural chemistry · 2023Article
- In Vitro and Ex Vivo Biofilm-Forming Ability ofJournal of fungi (Basel, Switzerland) · 2023Article
- Biophysical Characterization of the C-Terminal Tail ofACS omega · 2023Article
- Dermatophyte infection: from fungal pathogenicity to host immune responses.Frontiers in immunology · 2023Review
- Therapeutic Textiles Functionalized with Keratin-Based Particles Encapsulating Terbinafine for the Treatment of Onychomycosis.International journal of molecular sciences · 2022Article
- State-of-the-Art Dermatophyte Infections: Epidemiology Aspects, Pathophysiology, and Resistance Mechanisms.Journal of fungi (Basel, Switzerland) · 2021Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Keratin is important and needed for the growth of dermatophytes in the host tissue. In turn, the ability to invade keratinised tissues is defined as a pivotal virulence attribute of this group of medically important fungi. The host-dermatophyte interaction is accompanied by an adaptation of fungal metabolism that allows them to adhere to the host tissue as well as utilize the available nutrients necessary for their survival and growth. Dermatophyte infections pose a significant epidemiological and clinical problem. Trichophyton rubrum is the most common anthropophilic dermatophyte worldwide and its typical infection areas include skin of hands or feet and nail plate. In turn, Microsporum canis is a zoophilic pathogen, and mostly well known for ringworm in pets, it is also known to infect humans. The aim of the study was to compare the intracellular metabolite content in the T. rubrum and M. canis during keratin degradation using liquid chromatography system coupled with tandem mass spectrometer (LC-MS/MS). The metabolite "fingerprints" revealed compounds associated with amino acids metabolism, carbohydrate metabolism related to the glycolysis and the tricarboxylic acid cycle (TCA), as well as nucleotide and energy metabolism. The metabolites such as kynurenic acid, L-alanine and cysteine in case of T. rubrum as well as cysteine and riboflavin in case of M. canis were detected only during keratin degradation what may suggest that these compounds may play a key role in the interactions of T. rubrum and M. canis with the host tissue. The metabolomic results were completed by qPCR gene expression assay. Our findings suggest that metabolomic analysis of T. rubrum and M. canis growing in culture media that mimic the dermatophyte infection could allow the understanding of processes involved in the pathogenesis of dermatophytes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.