Evidence map›Paper›PMID 33600443›Full record

ArticlePloS one2021

Insular functional organization during handgrip in females and males with obstructive sleep apnea.

Amrita Pal, Jennifer A Ogren, Ravi S Aysola, Rajesh Kumar, Luke A Henderson, Ronald M Harper, Paul M Macey

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Obstructive sleep apnea and non-dipper: epiphenomena or risks of Alzheimer's disease?: a review from the HOPE Asia Network.Hypertension research : official journal of the Japanese Society of Hypertension · 2024
    Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Amrita PalUCLA School of Nursing, University of California, Los Angeles, California, United States of America.ORCID 0000-0001-9983-6286
Jennifer A OgrenDepartment of Neurobiology, University of California, Los Angeles, California, United States of America.
Ravi S AysolaDivision of Pulmonary and Critical Care, David Geffen School of Medicine at UCLA, University of California, Los Angeles, California, United States of America.
Rajesh KumarDepartment of Anesthesiology, University of California, Los Angeles, California, United States of America.
Luke A HendersonDepartment of Anatomy and Histology, Sydney Medical School, University of Sydney, Sydney, Australia.
Ronald M HarperDepartment of Neurobiology, University of California, Los Angeles, California, United States of America.
Paul M MaceyUCLA School of Nursing, University of California, Los Angeles, California, United States of America.
University of California, Los Angeles · USThe University of Sydney · AU

Funding

GABA and glutamate changes underlying altered autonomic function in obstructive sleep apneaR01HL135562 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MACEY, PAUL M, THOMAS, MICHAEL ALBERT · 2018 to 2021
$2.9M
Obstructive Sleep Apnea, Gender Biology, and Autonomic RegulationR01NR013693 · NINR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MACEY, PAUL M · 2013 to 2017
$2.0M
Sex-specific brain injury and symptoms in sleep apneaR56NR017435 · NINR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MACEY, PAUL M · 2018 to 2018
$300k
NHLBI NIH HHS R01 HL135562NINR NIH HHS R01 NR013693NINR NIH HHS R56 NR017435
6 · The paper itself

Abstract

STUDY

objectivesBrain regulation of autonomic function in obstructive sleep apnea (OSA) is disrupted in a sex-specific manner, including in the insula, which may contribute to several comorbidities. The insular gyri have anatomically distinct functions with respect to autonomic nervous system regulation; yet, OSA exerts little effect on the organization of insular gyral responses to sympathetic components of an autonomic challenge, the Valsalva. We further assessed neural responses of insular gyri in people with OSA to a static handgrip task, which principally involves parasympathetic withdrawal.

methodsWe measured insular function with blood oxygen level dependent functional MRI. We studied 48 newly-diagnosed OSA (age mean±std:46.5±9 years; AHI±std:32.6±21.1 events/hour; 36 male) and 63 healthy (47.2±8.8 years;40 male) participants. Subjects performed four 16s handgrips (1 min intervals, 80% subjective maximum strength) during scanning. fMRI time trends from five insular gyri-anterior short (ASG); mid short (MSG); posterior short (PSG); anterior long (ALG); and posterior long (PLG)-were assessed for within-group responses and between-group differences with repeated measures ANOVA (p<0.05) in combined and separate female-male models; age and resting heart-rate (HR) influences were also assessed.

resultsFemales showed greater right anterior dominance at the ASG, but no differences emerged between OSA and controls in relation to functional organization of the insula in response to handgrip. Males showed greater left anterior dominance at the ASG, but there were also no differences between OSA and controls. The males showed a group difference between OSA and controls only in the ALG. OSA males had lower left activation at the ALG compared to control males. Responses were mostly influenced by HR and age; however, age did not impact the response for right anterior dominance in females.

conclusionsInsular gyri functional responses to handgrip differ in OSA vs controls in a sex-based manner, but only in laterality of one gyrus, suggesting anterior and right-side insular dominance during sympathetic activation but parasympathetic withdrawal is largely intact, despite morphologic injury to the overall structure.

Indexed as

Hand StrengthAdultAutonomic Nervous SystemCerebral CortexFemaleHumansMaleMiddle AgedSleep Apnea, Obstructive

Identifiers

PMID33600443
PMCPMC7891756
OpenAlexW3130289246

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.